Triethyllead-restrained myelin deposition and protein synthesis in the developing rat forebrain

G. Konat, Halina Offner, J. Clausen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

20-day-old rats were acutely intoxicated with triethyllead (PbEt3). The forebrains of the poisoned and control animals were analyzed on postpartum days 27 or 34, or both. Two myelin subfractions, namely membrane- and myelin-fraction, were isolated. In the forebrains of PbEt3-treated rats, the deposition of the membrane-fraction was hampered to a greater extent than the deposition of the myelin-fraction. The intoxication caused a significant reduction in the concentration of sulphatides in the myelin-fraction. How-ever, in spite of sulphatides, the intoxication did not influence the protein or lipid content of either subfraction. A close correlation between the degree of inhibition of myelin deposition and of synthesis of myelin proteins was demonstrated in the forebrains of PbEt3-intoxicated rats. On the other hand, the synthesis of total forebrain protein was less depressed than the synthesis of myelin or its proteins, suggesting greater vulnerability of the myelin-forming cells than other cells in the brain tissue toward PbEt3-induced intoxication.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalExperimental Neurology
Volume52
Issue number1
DOIs
StatePublished - 1976
Externally publishedYes

Fingerprint

Myelin Proteins
Myelin Sheath
Prosencephalon
Sulfoglycosphingolipids
Proteins
Membranes
triethyllead
Postpartum Period
Lipids
Brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Triethyllead-restrained myelin deposition and protein synthesis in the developing rat forebrain. / Konat, G.; Offner, Halina; Clausen, J.

In: Experimental Neurology, Vol. 52, No. 1, 1976, p. 58-65.

Research output: Contribution to journalArticle

@article{4aa2c422217c450992b683a236156425,
title = "Triethyllead-restrained myelin deposition and protein synthesis in the developing rat forebrain",
abstract = "20-day-old rats were acutely intoxicated with triethyllead (PbEt3). The forebrains of the poisoned and control animals were analyzed on postpartum days 27 or 34, or both. Two myelin subfractions, namely membrane- and myelin-fraction, were isolated. In the forebrains of PbEt3-treated rats, the deposition of the membrane-fraction was hampered to a greater extent than the deposition of the myelin-fraction. The intoxication caused a significant reduction in the concentration of sulphatides in the myelin-fraction. How-ever, in spite of sulphatides, the intoxication did not influence the protein or lipid content of either subfraction. A close correlation between the degree of inhibition of myelin deposition and of synthesis of myelin proteins was demonstrated in the forebrains of PbEt3-intoxicated rats. On the other hand, the synthesis of total forebrain protein was less depressed than the synthesis of myelin or its proteins, suggesting greater vulnerability of the myelin-forming cells than other cells in the brain tissue toward PbEt3-induced intoxication.",
author = "G. Konat and Halina Offner and J. Clausen",
year = "1976",
doi = "10.1016/0014-4886(76)90200-4",
language = "English (US)",
volume = "52",
pages = "58--65",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Triethyllead-restrained myelin deposition and protein synthesis in the developing rat forebrain

AU - Konat, G.

AU - Offner, Halina

AU - Clausen, J.

PY - 1976

Y1 - 1976

N2 - 20-day-old rats were acutely intoxicated with triethyllead (PbEt3). The forebrains of the poisoned and control animals were analyzed on postpartum days 27 or 34, or both. Two myelin subfractions, namely membrane- and myelin-fraction, were isolated. In the forebrains of PbEt3-treated rats, the deposition of the membrane-fraction was hampered to a greater extent than the deposition of the myelin-fraction. The intoxication caused a significant reduction in the concentration of sulphatides in the myelin-fraction. How-ever, in spite of sulphatides, the intoxication did not influence the protein or lipid content of either subfraction. A close correlation between the degree of inhibition of myelin deposition and of synthesis of myelin proteins was demonstrated in the forebrains of PbEt3-intoxicated rats. On the other hand, the synthesis of total forebrain protein was less depressed than the synthesis of myelin or its proteins, suggesting greater vulnerability of the myelin-forming cells than other cells in the brain tissue toward PbEt3-induced intoxication.

AB - 20-day-old rats were acutely intoxicated with triethyllead (PbEt3). The forebrains of the poisoned and control animals were analyzed on postpartum days 27 or 34, or both. Two myelin subfractions, namely membrane- and myelin-fraction, were isolated. In the forebrains of PbEt3-treated rats, the deposition of the membrane-fraction was hampered to a greater extent than the deposition of the myelin-fraction. The intoxication caused a significant reduction in the concentration of sulphatides in the myelin-fraction. How-ever, in spite of sulphatides, the intoxication did not influence the protein or lipid content of either subfraction. A close correlation between the degree of inhibition of myelin deposition and of synthesis of myelin proteins was demonstrated in the forebrains of PbEt3-intoxicated rats. On the other hand, the synthesis of total forebrain protein was less depressed than the synthesis of myelin or its proteins, suggesting greater vulnerability of the myelin-forming cells than other cells in the brain tissue toward PbEt3-induced intoxication.

UR - http://www.scopus.com/inward/record.url?scp=0017140280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017140280&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(76)90200-4

DO - 10.1016/0014-4886(76)90200-4

M3 - Article

C2 - 954911

AN - SCOPUS:0017140280

VL - 52

SP - 58

EP - 65

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -