Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient

Hope Barone, Ross Brockman, Luke Johnson, Amira Al-Uzri, Mary Wright, Stephanie Mengden-Koon, Tracy Funk

Research output: Contribution to journalArticle

Abstract

Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin-colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9-year-old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. The clinical presentation of TS in this case morphologically resembled the more common, harmless skin condition known as “lichen nitidus,” and was more extensive than expected for TS, creating a diagnostic challenge. This case illustrates an important presentation of severe TS of which transplant teams, oncologists, primary care providers, and dermatologists should be aware.

Original languageEnglish (US)
Article numbere13394
JournalPediatric transplantation
Volume23
Issue number4
DOIs
StatePublished - Jun 2019

Keywords

  • antibody-mediated rejection
  • donor-specific antibodies
  • intravenous gamma globulin
  • polymerase chain reaction
  • trichodysplasia spinulosa
  • trichodysplasia spinulosa-associated polyomavirus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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  • Cite this

    Barone, H., Brockman, R., Johnson, L., Al-Uzri, A., Wright, M., Mengden-Koon, S., & Funk, T. (2019). Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient. Pediatric transplantation, 23(4), [e13394]. https://doi.org/10.1111/petr.13394