TRH induced growth hormone (GH) release in rats of both sexes: changes in pituitary response after gonadectomy and during the estrous cycle

Sergio Ojeda, A. Castro Vazquez, S. M. McCann

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In both intact adult male and female rats anesthetized with tribromoethanol, the iv injection of thyrotropin releasing hormone (TRH) evoked GH release within 2 min following the injection. The GH response to TRH was greater in males than in females and this response was significantly diminished by short term (6 days) orchidectomy. In females, the GH response to TRH was maximal in estrus and minimal in diestrus day 2, showing intermediate values at proestrus and diestrus day 1. Longterm ovariectomy decreased the response. Pituitary GH content and concentration were higher in males than in females. Orchidectomy was followed by a significant decrease in pituitary GH values, whereas ovariectomy resulted in increased GH content and concentration. The results indicate that the gonads can modify pituitary GH response to TRH and, therefore, play a physiological role in modulating the stimulatory effect that the hypothalamus exerts on GH release through the secretion of substances with GH releasing activity.

Original languageEnglish (US)
Pages (from-to)254-258
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume154
Issue number2
StatePublished - 1977
Externally publishedYes

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Thyrotropin-Releasing Hormone
Estrous Cycle
Growth Hormone
Rats
Diestrus
Orchiectomy
Ovariectomy
Proestrus
Injections
Estrus
Gonads
Hypothalamus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "In both intact adult male and female rats anesthetized with tribromoethanol, the iv injection of thyrotropin releasing hormone (TRH) evoked GH release within 2 min following the injection. The GH response to TRH was greater in males than in females and this response was significantly diminished by short term (6 days) orchidectomy. In females, the GH response to TRH was maximal in estrus and minimal in diestrus day 2, showing intermediate values at proestrus and diestrus day 1. Longterm ovariectomy decreased the response. Pituitary GH content and concentration were higher in males than in females. Orchidectomy was followed by a significant decrease in pituitary GH values, whereas ovariectomy resulted in increased GH content and concentration. The results indicate that the gonads can modify pituitary GH response to TRH and, therefore, play a physiological role in modulating the stimulatory effect that the hypothalamus exerts on GH release through the secretion of substances with GH releasing activity.",
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