Trends in invasive methicillin-resistant Staphylococcus aureus infections

Martha Iwamoto, Yi Mu, Ruth Lynfield, Sandra N. Bulens, Joelle Nadle, Deborah Aragon, Susan Petit, Susan M. Ray, Lee H. Harrison, Ghinwa Dumyati, John Townes, William Schaffner, Rachel J. Gorwitz, Fernanda C. Lessa

Research output: Contribution to journalArticle

73 Scopus citations


Objective: To describe trends in the incidence of invasive methicillinresistant Staphylococcus aureus (MRSA) infections in children during 2005-2010. Methods: We evaluated reports of invasive MRSA infections in pediatric patients identified from population-based surveillance during 2005-2010. Cases were defined as isolation of MRSA from a normally sterile site and classified on the basis of the setting of the positive culture and presence or absence of health care exposures. Estimated annual changes in incidence were determined by using regression models. National age- and race-specific incidences for 2010 were estimated by using US census data. Results: A total of 876 pediatric cases were reported; 340 (39%) were among infants. Overall, 35% of cases were hospital-onset, 23% were health care-associated community-onset, and 42% were communityassociated (CA). The incidence of invasive CA-MRSA infection per 100 000 children increased from 1.1 in 2005 to 1.7 in 2010 (modeled yearly increase: 10.2%; 95% confidence interval: 2.7%-18.2%). No significant trends were observed for health care-associated community-onset and hospital-onset cases. Nationally, estimated invasive MRSA incidence in 2010 was higher among infants aged

Original languageEnglish (US)
Issue number4
Publication statusPublished - Oct 2013



  • Children
  • Epidemiology
  • Infants
  • Methicillin resistance
  • Staphylococcus aureus infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Arts and Humanities (miscellaneous)

Cite this

Iwamoto, M., Mu, Y., Lynfield, R., Bulens, S. N., Nadle, J., Aragon, D., ... Lessa, F. C. (2013). Trends in invasive methicillin-resistant Staphylococcus aureus infections. Pediatrics, 132(4).