Trends and disparities in antiretroviral therapy initiation and Virologic suppression among newly treatment-eligible HIV-infected individuals in North America, 2001-2009

David B. Hanna, Kate Buchacz, Kelly A. Gebo, Nancy A. Hessol, Michael A. Horberg, Lisa P. Jacobson, Gregory D. Kirk, Mari M. Kitahata, Philip (Todd) Korthuis, Richard D. Moore, Sonia Napravnik, Pragna Patel, Michael J. Silverberg, Timothy R. Sterling, James H. Willig, Bryan Lau, Keri N. Althoff, Heidi M. Crane, Ann C. Collier, Hasina SamjiJennifer E. Thorne, M. John Gill, Marina B. Klein, Jeffrey N. Martin, Benigno Rodriguez, Sean B. Rourke, Stephen J. Gange

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background. Since the mid-1990s, effective antiretroviral therapy (ART) regimens have improved in potency, tolerability, ease of use, and class diversity. We sought to examine trends in treatment initiation and resulting human immunodeficiency virus (HIV) virologic suppression in North America between 2001 and 2009, and demographic and geographic disparities in these outcomes.Methods. We analyzed data on HIV-infected individuals newly clinically eligible for ART (ie, first reported CD4+ count + count, and viral load, and documented psychosocial barriers to ART initiation, including non-injection drug abuse, alcohol abuse, and mental illness.Results. Among 10 692 HIV-infected individuals, the cumulative incidence of 6-month ART initiation increased from 51% in 2001 to 72% in 2009 (Ptrend trend

Original languageEnglish (US)
Pages (from-to)1174-1182
Number of pages9
JournalClinical Infectious Diseases
Volume56
Issue number8
DOIs
StatePublished - Apr 15 2013

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North America
HIV
Therapeutics
CD4 Lymphocyte Count
Viral Load
Alcoholism
Substance-Related Disorders
Demography
Incidence

Keywords

  • antiretroviral therapy
  • healthcare disparities
  • HIV
  • time factors
  • viral load

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Trends and disparities in antiretroviral therapy initiation and Virologic suppression among newly treatment-eligible HIV-infected individuals in North America, 2001-2009. / Hanna, David B.; Buchacz, Kate; Gebo, Kelly A.; Hessol, Nancy A.; Horberg, Michael A.; Jacobson, Lisa P.; Kirk, Gregory D.; Kitahata, Mari M.; Korthuis, Philip (Todd); Moore, Richard D.; Napravnik, Sonia; Patel, Pragna; Silverberg, Michael J.; Sterling, Timothy R.; Willig, James H.; Lau, Bryan; Althoff, Keri N.; Crane, Heidi M.; Collier, Ann C.; Samji, Hasina; Thorne, Jennifer E.; Gill, M. John; Klein, Marina B.; Martin, Jeffrey N.; Rodriguez, Benigno; Rourke, Sean B.; Gange, Stephen J.

In: Clinical Infectious Diseases, Vol. 56, No. 8, 15.04.2013, p. 1174-1182.

Research output: Contribution to journalArticle

Hanna, DB, Buchacz, K, Gebo, KA, Hessol, NA, Horberg, MA, Jacobson, LP, Kirk, GD, Kitahata, MM, Korthuis, PT, Moore, RD, Napravnik, S, Patel, P, Silverberg, MJ, Sterling, TR, Willig, JH, Lau, B, Althoff, KN, Crane, HM, Collier, AC, Samji, H, Thorne, JE, Gill, MJ, Klein, MB, Martin, JN, Rodriguez, B, Rourke, SB & Gange, SJ 2013, 'Trends and disparities in antiretroviral therapy initiation and Virologic suppression among newly treatment-eligible HIV-infected individuals in North America, 2001-2009', Clinical Infectious Diseases, vol. 56, no. 8, pp. 1174-1182. https://doi.org/10.1093/cid/cit003
Hanna, David B. ; Buchacz, Kate ; Gebo, Kelly A. ; Hessol, Nancy A. ; Horberg, Michael A. ; Jacobson, Lisa P. ; Kirk, Gregory D. ; Kitahata, Mari M. ; Korthuis, Philip (Todd) ; Moore, Richard D. ; Napravnik, Sonia ; Patel, Pragna ; Silverberg, Michael J. ; Sterling, Timothy R. ; Willig, James H. ; Lau, Bryan ; Althoff, Keri N. ; Crane, Heidi M. ; Collier, Ann C. ; Samji, Hasina ; Thorne, Jennifer E. ; Gill, M. John ; Klein, Marina B. ; Martin, Jeffrey N. ; Rodriguez, Benigno ; Rourke, Sean B. ; Gange, Stephen J. / Trends and disparities in antiretroviral therapy initiation and Virologic suppression among newly treatment-eligible HIV-infected individuals in North America, 2001-2009. In: Clinical Infectious Diseases. 2013 ; Vol. 56, No. 8. pp. 1174-1182.
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AU - Gill, M. John

AU - Klein, Marina B.

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