Treatment Site Reactions to Zyderm Collagen Implantation

NEIL A. SWANSON; JOHN G. STONER; RONALD J. SIEGLE; ALVIN R. SOLOMON

doi:10.1111/j.1524-4725.1983.tb00819.x

Treatment Site Reactions to Zyderm Collagen Implantation

NEIL A. SWANSON, JOHN G. STONER, RONALD J. SIEGLE, ALVIN R. SOLOMON

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Abstract

Abstract. Two cases of treatment site granulomatous reaction to Zyderm Collagen Implant that occurred in spite of a negative skin test are reported. A delayed hypersensitivity reaction to ZCI is suggested by the clinical time course and the histologic findings of hypersensitivity granulomas. Humoral immunity is also implicated in the reaction since elevated anti‐Zyderm serum antibodies and plasma cell infiltrates are present. Resolution of the clinical signs and symptoms occurred over several months with no treatment. The physician using ZCI should be aware of this rare adverse reaction. 1983 American Society for Dermatologic Surgery, Inc.

Original language	English (US)
Pages (from-to)	377-380
Number of pages	4
Journal	The Journal of Dermatologic Surgery and Oncology
Volume	9
Issue number	5
DOIs	https://doi.org/10.1111/j.1524-4725.1983.tb00819.x
State	Published - May 1983
Externally published	Yes

ASJC Scopus subject areas

Oncology
Dermatology

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10.1111/j.1524-4725.1983.tb00819.x

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abstract = "Abstract. Two cases of treatment site granulomatous reaction to Zyderm Collagen Implant that occurred in spite of a negative skin test are reported. A delayed hypersensitivity reaction to ZCI is suggested by the clinical time course and the histologic findings of hypersensitivity granulomas. Humoral immunity is also implicated in the reaction since elevated anti‐Zyderm serum antibodies and plasma cell infiltrates are present. Resolution of the clinical signs and symptoms occurred over several months with no treatment. The physician using ZCI should be aware of this rare adverse reaction. 1983 American Society for Dermatologic Surgery, Inc.",

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AU - SWANSON, NEIL A.

AU - STONER, JOHN G.

AU - SIEGLE, RONALD J.

AU - SOLOMON, ALVIN R.

PY - 1983/5

Y1 - 1983/5

N2 - Abstract. Two cases of treatment site granulomatous reaction to Zyderm Collagen Implant that occurred in spite of a negative skin test are reported. A delayed hypersensitivity reaction to ZCI is suggested by the clinical time course and the histologic findings of hypersensitivity granulomas. Humoral immunity is also implicated in the reaction since elevated anti‐Zyderm serum antibodies and plasma cell infiltrates are present. Resolution of the clinical signs and symptoms occurred over several months with no treatment. The physician using ZCI should be aware of this rare adverse reaction. 1983 American Society for Dermatologic Surgery, Inc.

AB - Abstract. Two cases of treatment site granulomatous reaction to Zyderm Collagen Implant that occurred in spite of a negative skin test are reported. A delayed hypersensitivity reaction to ZCI is suggested by the clinical time course and the histologic findings of hypersensitivity granulomas. Humoral immunity is also implicated in the reaction since elevated anti‐Zyderm serum antibodies and plasma cell infiltrates are present. Resolution of the clinical signs and symptoms occurred over several months with no treatment. The physician using ZCI should be aware of this rare adverse reaction. 1983 American Society for Dermatologic Surgery, Inc.

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Treatment Site Reactions to Zyderm Collagen Implantation

Abstract

ASJC Scopus subject areas

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