Treatment Site Reactions to Zyderm Collagen Implantation

NEIL A. SWANSON, JOHN G. STONER, RONALD J. SIEGLE, ALVIN R. SOLOMON

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Abstract. Two cases of treatment site granulomatous reaction to Zyderm Collagen Implant that occurred in spite of a negative skin test are reported. A delayed hypersensitivity reaction to ZCI is suggested by the clinical time course and the histologic findings of hypersensitivity granulomas. Humoral immunity is also implicated in the reaction since elevated anti‐Zyderm serum antibodies and plasma cell infiltrates are present. Resolution of the clinical signs and symptoms occurred over several months with no treatment. The physician using ZCI should be aware of this rare adverse reaction. 1983 American Society for Dermatologic Surgery, Inc.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalThe Journal of Dermatologic Surgery and Oncology
Volume9
Issue number5
DOIs
StatePublished - May 1983

ASJC Scopus subject areas

  • Oncology
  • Dermatology

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    SWANSON, NEIL. A., STONER, JOHN. G., SIEGLE, RONALD. J., & SOLOMON, ALVIN. R. (1983). Treatment Site Reactions to Zyderm Collagen Implantation. The Journal of Dermatologic Surgery and Oncology, 9(5), 377-380. https://doi.org/10.1111/j.1524-4725.1983.tb00819.x