Treatment of Sexual Precocity by Removal of a Luteinizing Hormone—Releasing Hormone Secreting Hamartoma

Robert A. Price, Peter A. Lee, A. Leland Albright, Oline Ronnekleiv

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A 1-year-old infant was initially seen with precocious puberty that progressed rapidly and was associated with episodic gonadotropin release. A computed tomographic metrizamide cisternogram showed a pedunculated mass below the tuber cinereum; the mass was resected. His pubertal development regressed, his accelerated growth ceased, and his hormone levels returned to the normal prepubertal range. Immunocytochemical studies of the tissue demonstrated luteinizing hormone—releasing hormone (LHRH) granules in the perikaryon of neurons and axons in the hamartoma and axons connecting the hamartoma to the tuber cinereum. These data suggest that such lesions cause pubertal development by stimulating gonadotropin secretion via episodic release of LHRH. If such lesions are pedunculated, operative resection may be the treatment of choice.

Original languageEnglish (US)
Pages (from-to)2247-2249
Number of pages3
JournalJAMA - Journal of the American Medical Association
Volume251
Issue number17
DOIs
StatePublished - May 4 1984
Externally publishedYes

Fingerprint

Tuber Cinereum
Hamartoma
Luteinizing Hormone
Gonadotropins
Axons
Metrizamide
Precocious Puberty
Growth Hormone
Reference Values
Neurons
Therapeutics
Sexual precocity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment of Sexual Precocity by Removal of a Luteinizing Hormone—Releasing Hormone Secreting Hamartoma. / Price, Robert A.; Lee, Peter A.; Albright, A. Leland; Ronnekleiv, Oline.

In: JAMA - Journal of the American Medical Association, Vol. 251, No. 17, 04.05.1984, p. 2247-2249.

Research output: Contribution to journalArticle

@article{21d46ff473e14c778d41abba2739b8bb,
title = "Treatment of Sexual Precocity by Removal of a Luteinizing Hormone—Releasing Hormone Secreting Hamartoma",
abstract = "A 1-year-old infant was initially seen with precocious puberty that progressed rapidly and was associated with episodic gonadotropin release. A computed tomographic metrizamide cisternogram showed a pedunculated mass below the tuber cinereum; the mass was resected. His pubertal development regressed, his accelerated growth ceased, and his hormone levels returned to the normal prepubertal range. Immunocytochemical studies of the tissue demonstrated luteinizing hormone—releasing hormone (LHRH) granules in the perikaryon of neurons and axons in the hamartoma and axons connecting the hamartoma to the tuber cinereum. These data suggest that such lesions cause pubertal development by stimulating gonadotropin secretion via episodic release of LHRH. If such lesions are pedunculated, operative resection may be the treatment of choice.",
author = "Price, {Robert A.} and Lee, {Peter A.} and Albright, {A. Leland} and Oline Ronnekleiv",
year = "1984",
month = "5",
day = "4",
doi = "10.1001/jama.1984.03340410055032",
language = "English (US)",
volume = "251",
pages = "2247--2249",
journal = "JAMA - Journal of the American Medical Association",
issn = "0002-9955",
publisher = "American Medical Association",
number = "17",

}

TY - JOUR

T1 - Treatment of Sexual Precocity by Removal of a Luteinizing Hormone—Releasing Hormone Secreting Hamartoma

AU - Price, Robert A.

AU - Lee, Peter A.

AU - Albright, A. Leland

AU - Ronnekleiv, Oline

PY - 1984/5/4

Y1 - 1984/5/4

N2 - A 1-year-old infant was initially seen with precocious puberty that progressed rapidly and was associated with episodic gonadotropin release. A computed tomographic metrizamide cisternogram showed a pedunculated mass below the tuber cinereum; the mass was resected. His pubertal development regressed, his accelerated growth ceased, and his hormone levels returned to the normal prepubertal range. Immunocytochemical studies of the tissue demonstrated luteinizing hormone—releasing hormone (LHRH) granules in the perikaryon of neurons and axons in the hamartoma and axons connecting the hamartoma to the tuber cinereum. These data suggest that such lesions cause pubertal development by stimulating gonadotropin secretion via episodic release of LHRH. If such lesions are pedunculated, operative resection may be the treatment of choice.

AB - A 1-year-old infant was initially seen with precocious puberty that progressed rapidly and was associated with episodic gonadotropin release. A computed tomographic metrizamide cisternogram showed a pedunculated mass below the tuber cinereum; the mass was resected. His pubertal development regressed, his accelerated growth ceased, and his hormone levels returned to the normal prepubertal range. Immunocytochemical studies of the tissue demonstrated luteinizing hormone—releasing hormone (LHRH) granules in the perikaryon of neurons and axons in the hamartoma and axons connecting the hamartoma to the tuber cinereum. These data suggest that such lesions cause pubertal development by stimulating gonadotropin secretion via episodic release of LHRH. If such lesions are pedunculated, operative resection may be the treatment of choice.

UR - http://www.scopus.com/inward/record.url?scp=84944656789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944656789&partnerID=8YFLogxK

U2 - 10.1001/jama.1984.03340410055032

DO - 10.1001/jama.1984.03340410055032

M3 - Article

C2 - 6368884

AN - SCOPUS:84944656789

VL - 251

SP - 2247

EP - 2249

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0002-9955

IS - 17

ER -