Treatment of severe reflux esophagitis with cimetidine and metoclopramide

David Lieberman, E. B. Keeffe

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Reflux esophagitis may be unresponsive to standard medical therapy with an H2-receptor antagonist drug. Twenty-five patients with chronic reflux esophagitis, refractory to cimetidine treatment alone, were randomly assigned in a double-blind design to receive cimetidine (1200 mg/d), in combination with metoclopramide (40 mg/d) or placebo. Nine of twelve patients receiving cimetidine with metoclopramide had significant symptomatic improvement at the end of the 8-week study period, compared with 3 of 12 patients receiving cimetidine with placebo (p

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalAnnals of Internal Medicine
Volume104
Issue number1
StatePublished - 1986

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Peptic Esophagitis
Metoclopramide
Cimetidine
Placebos
Histamine H2 Receptors
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment of severe reflux esophagitis with cimetidine and metoclopramide. / Lieberman, David; Keeffe, E. B.

In: Annals of Internal Medicine, Vol. 104, No. 1, 1986, p. 21-26.

Research output: Contribution to journalArticle

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