Treatment of recurrent herpes simplex labialis with oral acyclovir

Spotswood L. Spruance, Jeffery C.B. Stewart, Nathaniel H. Rowe, Mark B. McKeough, Gay Wenerstrom, Donna J. Freeman

Research output: Contribution to journalArticlepeer-review

150 Scopus citations


In a double-blind, randomized, patient-initiated clinical trial, 174 nonimmunocompromised patients with a history of virus-culture-confirmed herpes simplex labialis were treated with acyclovir capsules, 400 mg five times daily for 5 days, or placebo capsules. For 97% of the patients, treatment started within 1 h of the first sign or symptom of a recurrence. The frequency of positive lesion virus cultures was significantly lower among acyclovir-treated subjects (29/114,25%) than among placebo-treated subjects (29/60,48%; P =.004). Drug treatment did not affect the development of lesions, measured by the frequency of macular and papular (aborted) lesions and mean maximum lesion size. However, acyclovir hastened lesion resolution among the patients who could start treatment in the prodrome or erythema lesion stage. For this group, the mean duration of pain was reduced by 36% (P =.02)and the mean healing time to loss of crust by 27% (P =.03). Thus, oral acyclovir alleviated some of the clinical manifestations of herpes simplex labialis.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalJournal of Infectious Diseases
Issue number2
StatePublished - Feb 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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