Treatment of primary hyperoxaluria type 1 with sequential liver and kidney transplants from the same living donor

Gregory S. Rosenblatt, Randall Jenkins, John Barry

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Alanine-glyoxalate aminotransferase deficiency occurs in patients with primary hyperoxaluria type 1. Increased hepatic oxalate production leads to high urine concentrations of glycolate and oxalate. Calcium oxalate nephrolithiasis and nephrocalcinosis occur, and renal function progressively declines until patients develop end-stage renal disease. Renal transplantation alone is inadequate therapy because the primary enzyme deficiency remains. We report what we believe to be the second-youngest recipient to undergo successful sequential liver and kidney transplantation from a single living-related donor for treatment of primary hyperoxaluria type 1. We also discuss the changes in this patient's serum oxalate levels after transplantation.

Original languageEnglish (US)
JournalUrology
Volume68
Issue number2
DOIs
StatePublished - Aug 2006

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Oxalates
Living Donors
glycolic acid
Transplants
Kidney
Kidney Transplantation
Liver
Nephrocalcinosis
Alanine Transaminase
Liver Transplantation
Chronic Kidney Failure
Therapeutics
Transplantation
Urine
Enzymes
Serum
Primary hyperoxaluria type 1

ASJC Scopus subject areas

  • Urology

Cite this

Treatment of primary hyperoxaluria type 1 with sequential liver and kidney transplants from the same living donor. / Rosenblatt, Gregory S.; Jenkins, Randall; Barry, John.

In: Urology, Vol. 68, No. 2, 08.2006.

Research output: Contribution to journalArticle

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