TY - JOUR
T1 - Treatment of Parkinson's Disease with Sodium Valproate
T2 - Clinical, Pharmacological, and Biochemical Observations
AU - Nutt, John
AU - Williams, Adrian
AU - Plotkin, Charles
AU - Eng, Nancy
AU - Ziegler, Michael
AU - Calne, Donald B.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1979/8
Y1 - 1979/8
N2 - Because there is biochemical evidence of decreased GABAergic function in Parkinson's disease, sodium valproate, an inhibitor of GA BA catabolism, was administered to eight Parkinsonian patients. Valproate treatment did not significantly alter any Parkinsonian feature, but tended to increase the dyskinesia in the “on-off” patients. The increased dyskinesias were not a result of altered peripheral metabolism of L-dopa. Despite obtaining high plasma levels of valproate, no consistent alteration of CSF GABA levels could be demonstrated. Thus, in these patients, an effect of valproate on GABA metabolism is unproven, and in turn, the role of GABA in Parkinsonism and dyskinesia uncertain.
AB - Because there is biochemical evidence of decreased GABAergic function in Parkinson's disease, sodium valproate, an inhibitor of GA BA catabolism, was administered to eight Parkinsonian patients. Valproate treatment did not significantly alter any Parkinsonian feature, but tended to increase the dyskinesia in the “on-off” patients. The increased dyskinesias were not a result of altered peripheral metabolism of L-dopa. Despite obtaining high plasma levels of valproate, no consistent alteration of CSF GABA levels could be demonstrated. Thus, in these patients, an effect of valproate on GABA metabolism is unproven, and in turn, the role of GABA in Parkinsonism and dyskinesia uncertain.
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U2 - 10.1017/S0317167100023970
DO - 10.1017/S0317167100023970
M3 - Article
C2 - 385131
AN - SCOPUS:0018675782
SN - 0317-1671
VL - 6
SP - 337
EP - 343
JO - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
JF - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
IS - 3
ER -