Treatment of huntington disease with a cholinergic agonist

John Nutt, Arnold Rosin, Thomas N. Chase

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The involuntary movements of Huntington disease may be related to cholinergic hypofunction in the striatum. For this reason, the effect of a direct cholinergic agonist, arecoline, was studied in six patients with this disorder. Rather than improving the chorea, arecoline tended to exacerbate the choreic movements. Arecoline did produce significant alterations of blood pressure, heart rate, and body temperature, probably by central cholinergic stimulation.

Original languageEnglish (US)
Pages (from-to)1061-1064
Number of pages4
JournalNeurology
Volume28
Issue number10
StatePublished - 1978
Externally publishedYes

Fingerprint

Arecoline
Cholinergic Agonists
Huntington Disease
Chorea
Cholinergic Agents
Dyskinesias
Body Temperature
Therapeutics
Heart Rate
Blood Pressure

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Nutt, J., Rosin, A., & Chase, T. N. (1978). Treatment of huntington disease with a cholinergic agonist. Neurology, 28(10), 1061-1064.

Treatment of huntington disease with a cholinergic agonist. / Nutt, John; Rosin, Arnold; Chase, Thomas N.

In: Neurology, Vol. 28, No. 10, 1978, p. 1061-1064.

Research output: Contribution to journalArticle

Nutt, J, Rosin, A & Chase, TN 1978, 'Treatment of huntington disease with a cholinergic agonist', Neurology, vol. 28, no. 10, pp. 1061-1064.
Nutt, John ; Rosin, Arnold ; Chase, Thomas N. / Treatment of huntington disease with a cholinergic agonist. In: Neurology. 1978 ; Vol. 28, No. 10. pp. 1061-1064.
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