Treatment of huntington disease with a cholinergic agonist

John G. Nutt, Arnold Rosin, Thomas N. Chase

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Abstract

The involuntary movements of Huntington disease may be related to cholinergic hypofunction in the striatum. For this reason, the effect of a direct cholinergic agonist, arecoline, was studied in six patients with this disorder. Rather than improving the chorea, arecoline tended to exacerbate the choreic movements. Arecoline did produce significant alterations of blood pressure, heart rate, and body temperature, probably by central cholinergic stimulation.

Original languageEnglish (US)
Pages (from-to)1061-1064
Number of pages4
JournalNeurology
Volume28
Issue number10
StatePublished - Oct 1978

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ASJC Scopus subject areas

  • Clinical Neurology

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Nutt, J. G., Rosin, A., & Chase, T. N. (1978). Treatment of huntington disease with a cholinergic agonist. Neurology, 28(10), 1061-1064.