Treatment of gestational diabetes mellitus: Glyburide compared to subcutaneous insulin therapy and associated perinatal outcomes

Yvonne W. Cheng, Judith H. Chung, Ingrid Block-Kurbisch, Maribeth Inturrisi, Aaron Caughey

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective.To examine perinatal outcomes in women with gestational diabetes mellitus treated with glyburide compared to insulin injections. Study design.This is a retrospective cohort study of women diagnosed with gestational diabetes mellitus (GDM) who required pharmaceutical therapy and were enrolled in the Sweet Success California Diabetes and Pregnancy Program between 2001 and 2004, a California state-wide program. Women managed with glyburide were compared to women treated with insulin injections. Perinatal outcomes were compared using chi-square test and multivariable logistic regression models; statistical significance was indicated by p <0.05 and 95% confidence intervals (CI). Results.Among the 10,682 women with GDM who required medical therapy and met study criteria, 2073 (19.4%) received glyburide and 8609 (80.6%) received subcutaneous insulin injections. Compared to insulin therapy and controlling for confounders, oral hypoglycemic treatment was associated with increased risk of birthweight >4000 g (aOR = 1.29; 95% CI [1.031.64]), and admission to the intensive care nursery (aOR = 1.46 [1.072.00]). Conclusion.Neonates born to women with gestational diabetes managed on glyburide, and were more likely to be macrosomic and to be admitted to the intensive care unit compared to those treated with insulin injections. These findings should be examined in a large, prospective trial.

Original languageEnglish (US)
Pages (from-to)379-384
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume25
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Gestational Diabetes
Glyburide
Insulin
Injections
Logistic Models
Therapeutics
Nurseries
Chi-Square Distribution
Critical Care
Intensive Care Units
Cohort Studies
Retrospective Studies
Newborn Infant
Pregnancy
Pharmaceutical Preparations

Keywords

  • Gestational diabetes mellitus
  • perinatal outcomes
  • treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Treatment of gestational diabetes mellitus : Glyburide compared to subcutaneous insulin therapy and associated perinatal outcomes. / Cheng, Yvonne W.; Chung, Judith H.; Block-Kurbisch, Ingrid; Inturrisi, Maribeth; Caughey, Aaron.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 25, No. 4, 04.2012, p. 379-384.

Research output: Contribution to journalArticle

Cheng, Yvonne W. ; Chung, Judith H. ; Block-Kurbisch, Ingrid ; Inturrisi, Maribeth ; Caughey, Aaron. / Treatment of gestational diabetes mellitus : Glyburide compared to subcutaneous insulin therapy and associated perinatal outcomes. In: Journal of Maternal-Fetal and Neonatal Medicine. 2012 ; Vol. 25, No. 4. pp. 379-384.
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