Treatment of erectile dysfunction following therapy for clinically localized prostate cancer: Patient reported use and outcomes from the Surveillance, Epidemiology, and End Results Prostate Cancer Outcomes Study

Robert A. Stephenson, Motomi (Tomi) Mori, Yi Ching Hsieh, Tomasz (Tom) Beer, Janet L. Stanford, Frank D. Gilliland, Richard M. Hoffman, Arnold L. Potosky

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Purpose: Erectile dysfunction (ED) persists for years following curative therapies for clinically localized prostate cancer. We report use and treatment outcomes in a 5-year interval in a population based cohort from the Surveillance, Epidemiology, and End Results Prostate Cancer Outcomes Study. Materials and Methods: A sample of 1,977 men with localized prostate cancer who received external beam radiation therapy or radical prostatectomy in 1994 to 1995 were surveyed for 5 outcome measures of ED treatment, namely treatment, perceived helpfulness, erectile sufficiency, sexual activity frequency and erection maintenance. Subjects were surveyed 6, 12, 24 and 60 months after prostate cancer diagnosis. Results: Overall 50.5% of men ever used ED treatment. The use of ED treatments increased during the study course. Subject age, regular sexual partner and baseline sexual activity were factors positively associated with ED treatments. While it was used uncommonly (1.9%), a penile prosthesis was perceived as the most helpful ED treatment (helped a lot in 52% of respondents). Sildenafil helped a lot in 12% of respondents. Erectile fullness, erection maintenance and sexual activity frequency were modestly improved in men using ED treatment compared with those in men not using ED treatment. Conclusions: Approximately half of the patients in this population based cohort of men used ED treatment during the 5 years following prostate cancer diagnosis. Men using ED treatments had modest improvement in sexual function compared with men that in who did not receive ED treatment at 60 months. More effective treatments for ED following local therapy for prostate cancer are needed.

Original languageEnglish (US)
Pages (from-to)646-650
Number of pages5
JournalJournal of Urology
Volume174
Issue number2
DOIs
StatePublished - Aug 2005

Fingerprint

Erectile Dysfunction
Prostatic Neoplasms
Epidemiology
Outcome Assessment (Health Care)
Therapeutics
Sexual Behavior
Patient Reported Outcome Measures
Maintenance
Penile Prosthesis
Sexual Partners
Prostatectomy
Population
Radiotherapy

Keywords

  • Impotence
  • Penis
  • Prostate
  • Prostatic neoplasms
  • Treatment outcome

ASJC Scopus subject areas

  • Urology

Cite this

Treatment of erectile dysfunction following therapy for clinically localized prostate cancer : Patient reported use and outcomes from the Surveillance, Epidemiology, and End Results Prostate Cancer Outcomes Study. / Stephenson, Robert A.; Mori, Motomi (Tomi); Hsieh, Yi Ching; Beer, Tomasz (Tom); Stanford, Janet L.; Gilliland, Frank D.; Hoffman, Richard M.; Potosky, Arnold L.

In: Journal of Urology, Vol. 174, No. 2, 08.2005, p. 646-650.

Research output: Contribution to journalArticle

@article{914c3465afd84d6eb01017480bbd24c4,
title = "Treatment of erectile dysfunction following therapy for clinically localized prostate cancer: Patient reported use and outcomes from the Surveillance, Epidemiology, and End Results Prostate Cancer Outcomes Study",
abstract = "Purpose: Erectile dysfunction (ED) persists for years following curative therapies for clinically localized prostate cancer. We report use and treatment outcomes in a 5-year interval in a population based cohort from the Surveillance, Epidemiology, and End Results Prostate Cancer Outcomes Study. Materials and Methods: A sample of 1,977 men with localized prostate cancer who received external beam radiation therapy or radical prostatectomy in 1994 to 1995 were surveyed for 5 outcome measures of ED treatment, namely treatment, perceived helpfulness, erectile sufficiency, sexual activity frequency and erection maintenance. Subjects were surveyed 6, 12, 24 and 60 months after prostate cancer diagnosis. Results: Overall 50.5{\%} of men ever used ED treatment. The use of ED treatments increased during the study course. Subject age, regular sexual partner and baseline sexual activity were factors positively associated with ED treatments. While it was used uncommonly (1.9{\%}), a penile prosthesis was perceived as the most helpful ED treatment (helped a lot in 52{\%} of respondents). Sildenafil helped a lot in 12{\%} of respondents. Erectile fullness, erection maintenance and sexual activity frequency were modestly improved in men using ED treatment compared with those in men not using ED treatment. Conclusions: Approximately half of the patients in this population based cohort of men used ED treatment during the 5 years following prostate cancer diagnosis. Men using ED treatments had modest improvement in sexual function compared with men that in who did not receive ED treatment at 60 months. More effective treatments for ED following local therapy for prostate cancer are needed.",
keywords = "Impotence, Penis, Prostate, Prostatic neoplasms, Treatment outcome",
author = "Stephenson, {Robert A.} and Mori, {Motomi (Tomi)} and Hsieh, {Yi Ching} and Beer, {Tomasz (Tom)} and Stanford, {Janet L.} and Gilliland, {Frank D.} and Hoffman, {Richard M.} and Potosky, {Arnold L.}",
year = "2005",
month = "8",
doi = "10.1097/01.ju.0000165342.85300.14",
language = "English (US)",
volume = "174",
pages = "646--650",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Treatment of erectile dysfunction following therapy for clinically localized prostate cancer

T2 - Patient reported use and outcomes from the Surveillance, Epidemiology, and End Results Prostate Cancer Outcomes Study

AU - Stephenson, Robert A.

AU - Mori, Motomi (Tomi)

AU - Hsieh, Yi Ching

AU - Beer, Tomasz (Tom)

AU - Stanford, Janet L.

AU - Gilliland, Frank D.

AU - Hoffman, Richard M.

AU - Potosky, Arnold L.

PY - 2005/8

Y1 - 2005/8

N2 - Purpose: Erectile dysfunction (ED) persists for years following curative therapies for clinically localized prostate cancer. We report use and treatment outcomes in a 5-year interval in a population based cohort from the Surveillance, Epidemiology, and End Results Prostate Cancer Outcomes Study. Materials and Methods: A sample of 1,977 men with localized prostate cancer who received external beam radiation therapy or radical prostatectomy in 1994 to 1995 were surveyed for 5 outcome measures of ED treatment, namely treatment, perceived helpfulness, erectile sufficiency, sexual activity frequency and erection maintenance. Subjects were surveyed 6, 12, 24 and 60 months after prostate cancer diagnosis. Results: Overall 50.5% of men ever used ED treatment. The use of ED treatments increased during the study course. Subject age, regular sexual partner and baseline sexual activity were factors positively associated with ED treatments. While it was used uncommonly (1.9%), a penile prosthesis was perceived as the most helpful ED treatment (helped a lot in 52% of respondents). Sildenafil helped a lot in 12% of respondents. Erectile fullness, erection maintenance and sexual activity frequency were modestly improved in men using ED treatment compared with those in men not using ED treatment. Conclusions: Approximately half of the patients in this population based cohort of men used ED treatment during the 5 years following prostate cancer diagnosis. Men using ED treatments had modest improvement in sexual function compared with men that in who did not receive ED treatment at 60 months. More effective treatments for ED following local therapy for prostate cancer are needed.

AB - Purpose: Erectile dysfunction (ED) persists for years following curative therapies for clinically localized prostate cancer. We report use and treatment outcomes in a 5-year interval in a population based cohort from the Surveillance, Epidemiology, and End Results Prostate Cancer Outcomes Study. Materials and Methods: A sample of 1,977 men with localized prostate cancer who received external beam radiation therapy or radical prostatectomy in 1994 to 1995 were surveyed for 5 outcome measures of ED treatment, namely treatment, perceived helpfulness, erectile sufficiency, sexual activity frequency and erection maintenance. Subjects were surveyed 6, 12, 24 and 60 months after prostate cancer diagnosis. Results: Overall 50.5% of men ever used ED treatment. The use of ED treatments increased during the study course. Subject age, regular sexual partner and baseline sexual activity were factors positively associated with ED treatments. While it was used uncommonly (1.9%), a penile prosthesis was perceived as the most helpful ED treatment (helped a lot in 52% of respondents). Sildenafil helped a lot in 12% of respondents. Erectile fullness, erection maintenance and sexual activity frequency were modestly improved in men using ED treatment compared with those in men not using ED treatment. Conclusions: Approximately half of the patients in this population based cohort of men used ED treatment during the 5 years following prostate cancer diagnosis. Men using ED treatments had modest improvement in sexual function compared with men that in who did not receive ED treatment at 60 months. More effective treatments for ED following local therapy for prostate cancer are needed.

KW - Impotence

KW - Penis

KW - Prostate

KW - Prostatic neoplasms

KW - Treatment outcome

UR - http://www.scopus.com/inward/record.url?scp=22144452525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144452525&partnerID=8YFLogxK

U2 - 10.1097/01.ju.0000165342.85300.14

DO - 10.1097/01.ju.0000165342.85300.14

M3 - Article

C2 - 16006930

AN - SCOPUS:22144452525

VL - 174

SP - 646

EP - 650

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -