Treatment of acquired von Willebrand syndrome in childhood

Michael U. Callaghan, Trisha Wong, Augusto B. Federici

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 3-1/2-year-old male with no personal or family history of bleeding disorders presented with abdominal distension, epistaxis, and anemia (hemoglobin 8.2 g/dL). A magnetic resonance imaging scan of the abdomen demonstrated amass arising from the left kidney. Preoperative laboratory studies revealed a prolonged activated partial thromboplastin time of 49.2 seconds, a normal prothrombin time of 12.4 seconds, and a platelet count of 230 000/μL. Further testing revealed factor VIII (FVIII) activity of 16%, factor IX (FIX) activity of 74%, von Willebrand factor (VWF) activity of 12%, VWF antigen activity of 31%, and decreased high-molecular-weight VWF multimers consistent with acquired von Willebrand syndrome (AVWS). What is the best treatment for this child?

Original languageEnglish (US)
Pages (from-to)2019-2022
Number of pages4
JournalBlood
Volume122
Issue number12
DOIs
StatePublished - Sep 19 2013
Externally publishedYes

Fingerprint

von Willebrand Factor
Epistaxis
Factor IX
Partial Thromboplastin Time
Prothrombin Time
Factor VIII
Thromboplastin
Prothrombin
Magnetic resonance
Platelets
Platelet Count
Abdomen
Anemia
Hemoglobins
Therapeutics
Molecular Weight
Molecular weight
Magnetic Resonance Imaging
Hemorrhage
Kidney

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Treatment of acquired von Willebrand syndrome in childhood. / Callaghan, Michael U.; Wong, Trisha; Federici, Augusto B.

In: Blood, Vol. 122, No. 12, 19.09.2013, p. 2019-2022.

Research output: Contribution to journalArticle

Callaghan, Michael U. ; Wong, Trisha ; Federici, Augusto B. / Treatment of acquired von Willebrand syndrome in childhood. In: Blood. 2013 ; Vol. 122, No. 12. pp. 2019-2022.
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