Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments

Ramadevi Pullela, Jacob Raber, Timothy Pfankuch, Donna M. Ferriero, Catherine P. Claus, Seong Eun Koh, Toshihiro Yamauchi, Radoslaw Rola, John R. Fike, Linda J. Noble-Haeusslein

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

The immature brain may be particularly vulnerable to injury during critical periods of development. To address the biologic basis for this vulnerability, mice were subjected to traumatic brain injury at postnatal day 21, a time point that approximates that of the toddler-aged child. After motor and cognitive testing at either 2 weeks (juveniles) or 3 months (adults) after injury, animals were euthanized and the brains prepared for quantitative histologic assessment. Brain-injured mice exhibited hyperactivity and age-dependent anxiolysis. Cortical lesion volume and subcortical neuronal loss were greater in brain-injured adults than in juveniles. Importantly, cognitive decline was delayed in onset and coincided with loss of neurons in the hippocampus. Our findings demonstrate that trauma to the developing brain results in a prolonged period of pathogenesis in both cortical and subcortical structures. Behavioral changes are a likely consequence of regional-specific neuronal degeneration.

Original languageEnglish (US)
Pages (from-to)396-409
Number of pages14
JournalDevelopmental Neuroscience
Volume28
Issue number4-5
DOIs
StatePublished - Aug 1 2006

Keywords

  • Cognitive function
  • Delayed cell loss
  • Immature brain
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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    Pullela, R., Raber, J., Pfankuch, T., Ferriero, D. M., Claus, C. P., Koh, S. E., Yamauchi, T., Rola, R., Fike, J. R., & Noble-Haeusslein, L. J. (2006). Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments. Developmental Neuroscience, 28(4-5), 396-409. https://doi.org/10.1159/000094166