Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance: identity of laboratory constructed plasmids and clinical isolates

F. Heffron, C. Rubens, S. Falkow

    Research output: Contribution to journalArticle

    6 Scopus citations

    Abstract

    The structural gene for ampicillin resistance residues upon a 3.2 x 106 dalton sequence of deoxyribonucleic acid, TnA, that can be transposed from replicon to replicon in laboratory experiments. TnA was transposed from a large conjugative plasmid to a small nonconjugative plasmid, RSF1010. Several RSF1010::TnA plasmids isolated in these laboratory experiments have been shown to be identical to plasmids found in clinical isolates. These data provide direct support to the theory that transposition of drug resistance genes play a key role in the evolution of R plasmids.

    Original languageEnglish (US)
    Pages (from-to)530-533
    Number of pages4
    JournalJournal of bacteriology
    Volume129
    Issue number1
    StatePublished - Jan 1 1977

    ASJC Scopus subject areas

    • Microbiology
    • Molecular Biology

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