Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance: identity of laboratory constructed plasmids and clinical isolates

Fred Heffron, C. Rubens, S. Falkow

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The structural gene for ampicillin resistance residues upon a 3.2 x 106 dalton sequence of deoxyribonucleic acid, TnA, that can be transposed from replicon to replicon in laboratory experiments. TnA was transposed from a large conjugative plasmid to a small nonconjugative plasmid, RSF1010. Several RSF1010::TnA plasmids isolated in these laboratory experiments have been shown to be identical to plasmids found in clinical isolates. These data provide direct support to the theory that transposition of drug resistance genes play a key role in the evolution of R plasmids.

Original languageEnglish (US)
Pages (from-to)530-533
Number of pages4
JournalJournal of Bacteriology
Volume129
Issue number1
StatePublished - 1977
Externally publishedYes

Fingerprint

Ampicillin Resistance
Plasmids
Replicon
DNA
R Factors
Drug Resistance
Genes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance : identity of laboratory constructed plasmids and clinical isolates. / Heffron, Fred; Rubens, C.; Falkow, S.

In: Journal of Bacteriology, Vol. 129, No. 1, 1977, p. 530-533.

Research output: Contribution to journalArticle

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