The structural gene for ampicillin resistance residues upon a 3.2 x 106 dalton sequence of deoxyribonucleic acid, TnA, that can be transposed from replicon to replicon in laboratory experiments. TnA was transposed from a large conjugative plasmid to a small nonconjugative plasmid, RSF1010. Several RSF1010::TnA plasmids isolated in these laboratory experiments have been shown to be identical to plasmids found in clinical isolates. These data provide direct support to the theory that transposition of drug resistance genes play a key role in the evolution of R plasmids.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of bacteriology|
|State||Published - Jan 1 1977|
ASJC Scopus subject areas
- Molecular Biology