Transplantation of insulin-like growth factor-II-secreting tumors into nude rodents

D. M. Wilson, J. A. Thomas, T. E. Hamm, J. Wyche, R. L. Hintz, Ronald (Ron) Rosenfeld

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Restricted supplies of insulin-like growth factor II (IGF-II) have severely limited investigations of the in vivo actions of this hormone. To circumvent this problem, we have developed an in vivo rodent model in which rat (r) IGF-II-secreting cells (18, 54-SF) are transplanted into congenitally immunodeficient (nude) rats and mice. These cells proliferate and form discrete tumors that contain rIGF-II and abundant IGF-II receptors. The tumors also secrete rIGF-II into the circulation, resulting in plasma rIGF-II concentrations many-fold greater than those in control rodents (81 ± 19 vs.

Original languageEnglish (US)
Pages (from-to)1896-1901
Number of pages6
JournalEndocrinology
Volume120
Issue number5
StatePublished - 1987
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor II
Rodentia
Rodent Control
Transplantation
Nude Rats
IGF Type 2 Receptor
Nude Mice
Neoplasms
Hormones
rat insulin-like growth factor II

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Wilson, D. M., Thomas, J. A., Hamm, T. E., Wyche, J., Hintz, R. L., & Rosenfeld, R. R. (1987). Transplantation of insulin-like growth factor-II-secreting tumors into nude rodents. Endocrinology, 120(5), 1896-1901.

Transplantation of insulin-like growth factor-II-secreting tumors into nude rodents. / Wilson, D. M.; Thomas, J. A.; Hamm, T. E.; Wyche, J.; Hintz, R. L.; Rosenfeld, Ronald (Ron).

In: Endocrinology, Vol. 120, No. 5, 1987, p. 1896-1901.

Research output: Contribution to journalArticle

Wilson, DM, Thomas, JA, Hamm, TE, Wyche, J, Hintz, RL & Rosenfeld, RR 1987, 'Transplantation of insulin-like growth factor-II-secreting tumors into nude rodents', Endocrinology, vol. 120, no. 5, pp. 1896-1901.
Wilson DM, Thomas JA, Hamm TE, Wyche J, Hintz RL, Rosenfeld RR. Transplantation of insulin-like growth factor-II-secreting tumors into nude rodents. Endocrinology. 1987;120(5):1896-1901.
Wilson, D. M. ; Thomas, J. A. ; Hamm, T. E. ; Wyche, J. ; Hintz, R. L. ; Rosenfeld, Ronald (Ron). / Transplantation of insulin-like growth factor-II-secreting tumors into nude rodents. In: Endocrinology. 1987 ; Vol. 120, No. 5. pp. 1896-1901.
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