Transplacental gradients in the guinea pig.

L. L. Woods, Kent Thornburg, J. J. Faber

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    22 Citations (Scopus)

    Abstract

    We measured plasma concentrations of Na+, K+, Mg2+, Cl-, Ca2+, HCO3-, phosphate, lactate, glucose, total amino acids, and total protein, and also the total (freezing point depression) osmolality and the colloid osmotic pressures. Conversion of chemically measured concentrations to osmolalities showed that unrecognized solute (s) were present in maternal (7 mM) and fetal (12 mM) plasma. Statistically reliable transplacental gradients existed only for calcium ion, phosphate, and amino acids, Ionic Na, K Mg, Cl, Ca, HCO3 and lactate were in electrochemical equilibrium at potential differences of -4.2 to +1.3 mV. Total plasma osmolalities were not significantly different in maternal and fetal plasmas in preparations in good condition, but fetal plasma osmolalities rose due to lactate secretion in asphyxiated fetuses. Colloid osmotic pressures were about 5 cmH2O higher in maternal plasmas before 45 days gestation and about 6 cmH2O higher in fetal plasmas after 60 days gestation. In the guinea pig, colloid osmotic pressures are at least as important as intravascular pressures in the regulation of transplacental water flow.

    Original languageEnglish (US)
    JournalThe American journal of physiology
    Volume235
    Issue number2
    StatePublished - Aug 1978

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    Guinea Pigs
    Osmolar Concentration
    Osmotic Pressure
    Colloids
    Mothers
    Lactic Acid
    Amino Acids
    Pregnancy
    Freezing
    Fetus
    Phosphates
    Ions
    Pressure
    Glucose
    Water
    Proteins

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Transplacental gradients in the guinea pig. / Woods, L. L.; Thornburg, Kent; Faber, J. J.

    In: The American journal of physiology, Vol. 235, No. 2, 08.1978.

    Research output: Contribution to journalArticle

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