Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring

Lyndsey E. Shorey; David J. Castro; William M. Baird; Lisbeth K. Siddens; Christiane V. Löhr; Melissa M. Matzke; Katrina M. Waters; Richard A. Corley; David E. Williams

doi:10.1016/j.canlet.2011.11.010

Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring

Lyndsey E. Shorey, David J. Castro, William M. Baird, Lisbeth K. Siddens, Christiane V. Löhr, Melissa M. Matzke, Katrina M. Waters, Richard A. Corley, David E. Williams

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [ ¹⁴C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [ ¹⁴C] 3weeks post-dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.

Original language	English (US)
Pages (from-to)	49-55
Number of pages	7
Journal	Cancer Letters
Volume	317
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2011.11.010
State	Published - Apr 1 2012
Externally published	Yes

Keywords

Carcinogenesis
Fetal
Maternal
PAHs
T-cell lymphoma
Transplacental cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2011.11.010

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Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC) : Timing of maternal exposures determines target tissue response in offspring. / Shorey, Lyndsey E.; Castro, David J.; Baird, William M.; Siddens, Lisbeth K.; Löhr, Christiane V.; Matzke, Melissa M.; Waters, Katrina M.; Corley, Richard A.; Williams, David E.

In: Cancer Letters, Vol. 317, No. 1, 01.04.2012, p. 49-55.

Research output: Contribution to journal › Article › peer-review

Shorey, Lyndsey E. ; Castro, David J. ; Baird, William M. ; Siddens, Lisbeth K. ; Löhr, Christiane V. ; Matzke, Melissa M. ; Waters, Katrina M. ; Corley, Richard A. ; Williams, David E. / Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC) : Timing of maternal exposures determines target tissue response in offspring. In: Cancer Letters. 2012 ; Vol. 317, No. 1. pp. 49-55.

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abstract = "Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [ 14C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [ 14C] 3weeks post-dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.",

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Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring

Abstract

Keywords

ASJC Scopus subject areas

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