Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring

Lyndsey E. Shorey, David J. Castro, William M. Baird, Lisbeth K. Siddens, Christiane V. Löhr, Melissa M. Matzke, Katrina M. Waters, Richard A. Corley, David E. Williams

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [ 14C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [ 14C] 3weeks post-dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalCancer Letters
Volume317
Issue number1
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Keywords

  • Carcinogenesis
  • Fetal
  • Maternal
  • PAHs
  • T-cell lymphoma
  • Transplacental cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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