Transmitter regulation of voltage-dependant K+ channels expressed in Xenopus oocytes

M. P. Kavanaugh, M. J. Christie, P. B. Osborne, A. E. Busch, K. Z. Shen, Y. N.P.H. Wu Seeburg, J. P. Adelman, R. A. North

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 μM, 20-30 s application) by up to 90 %. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.

Original languageEnglish (US)
Pages (from-to)899-902
Number of pages4
JournalBiochemical Journal
Issue number3
StatePublished - 1991

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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