Transmitter regulation of voltage-dependant K+ channels expressed in Xenopus oocytes

M. P. Kavanaugh, M. J. Christie, P. B. Osborne, A. E. Busch, K. Z. Shen, Y. N.P.H. Wu Seeburg, J. P. Adelman, R. A. North

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Abstract

Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 μM, 20-30 s application) by up to 90 %. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.

Original languageEnglish (US)
Pages (from-to)899-902
Number of pages4
JournalBiochemical Journal
Volume277
Issue number3
DOIs
StatePublished - Jan 1 1991

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kavanaugh, M. P., Christie, M. J., Osborne, P. B., Busch, A. E., Shen, K. Z., Wu Seeburg, Y. N. P. H., Adelman, J. P., & North, R. A. (1991). Transmitter regulation of voltage-dependant K+ channels expressed in Xenopus oocytes. Biochemical Journal, 277(3), 899-902. https://doi.org/10.1042/bj2770899