Transmission of risk from parents with chronic pain to offspring

An integrative conceptual model

Amanda L. Stone, Anna Wilson

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Offspring of parents with chronic pain are at increased risk for pain and adverse mental and physical health outcomes (Higgins et al, 2015). Although the association between chronic pain in parents and offspring has been established, few studies have addressed why or how this relation occurs. Identifying mechanisms for the transmission of risk that leads to the development of chronic pain in offspring is important for developing preventive interventions targeted to decrease risk for chronic pain and related outcomes (eg, disability and internalizing symptoms). This review presents a conceptual model for the intergenerational transmission of chronic pain from parents to offspring with the goal of setting an agenda for future research and the development of preventive interventions. Our proposed model highlights 5 potential mechanisms for the relation between parental chronic pain and pediatric chronic pain and related adverse outcomes: (1) genetics, (2) alterations in early neurobiological development, (3) pain-specific social learning, (4), general parenting and family health, and (5) exposure to stressful environment. In addition, the model presents 3 potential moderators for the relation between parent and child chronic pain: (1) the presence of chronic pain in a second parent, (2) timing, course, and location of parental chronic pain, and (3) offspring's characteristics (ie, sex, developmental stage, race or ethnicity, and temperament). Such a framework highlights chronic pain as inherently familial and intergenerational, opening up avenues for new models of intervention and prevention that can be family centered and include at-risk children.

Original languageEnglish (US)
Pages (from-to)2628-2639
Number of pages12
JournalPain
Volume157
Issue number12
DOIs
StatePublished - Aug 10 2016

Fingerprint

Chronic Pain
Parents
Parent-Child Relations
Pain
Temperament
Family Health
Parenting
Sex Characteristics
Mental Health
Pediatrics

Keywords

  • Children
  • Chronic pain
  • Offspring
  • Parents

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Transmission of risk from parents with chronic pain to offspring : An integrative conceptual model. / Stone, Amanda L.; Wilson, Anna.

In: Pain, Vol. 157, No. 12, 10.08.2016, p. 2628-2639.

Research output: Contribution to journalReview article

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