@article{d01c384725e94949b335256a5bea21ca,
title = "Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition",
abstract = "Increased expression of the transcription/translation regulatory protein Y-box binding protein-1 (YB-1) is associated with cancer aggressiveness, particularly in breast carcinoma. Here we establish that YB-1 levels are elevated in invasive breast cancer cells and correlate with reduced expression of E-cadherin and poor patient survival. Enforced expression of YB-1 in noninvasive breast epithelial cells induced an epithelial-mesenchymal transition (EMT) accompanied by enhanced metastatic potential and reduced proliferation rates. YB-1 directly activates cap-independent translation of messenger RNAs encoding Snail1 and other transcription factors implicated in downregulation of epithelial and growth-related genes and activation of mesenchymal genes. Hence, translational regulation by YB-1 is a restriction point enabling coordinated expression of a network of EMT-inducing transcription factors, likely acting together to promote metastatic spread.",
keywords = "CELLCYCLE",
author = "Valentina Evdokimova and Cristina Tognon and Tony Ng and Peter Ruzanov and Natalya Melnyk and Dieter Fink and Alexey Sorokin and Ovchinnikov, {Lev P.} and Elai Davicioni and Triche, {Timothy J.} and Sorensen, {Poul H.B.}",
note = "Funding Information: We thank Sam Aparicio and Lena Preobrazhenskaya (BC Cancer Research Centre), Anna Krichevsky (Harvard Medical School), and Irina Groisman (University of Massachusetts Medical School) for critical reading of the manuscript; Betty Schaub, Dennis Mock, and Jonathan Buckley (Children's Hospital, Los Angeles, CA) for assistance with the Affymetrix gene expression data; and David Huntsman, Gulisa Turashvili, Torsten Nielsen, and Samuel Leung (Center for Translational and Applied Genomics) for providing breast cancer specimens. This work was supported by a grant from the Canadian Institute of Health Research (MOP62802-CIHR) to P.S. and V.E.; a ReThink Breast Cancer Career Development Award to C.E.T; and a fellowship from the Canadian Institute of Health Research, Michael Smith Foundation for Health Research, and the Royal College of Physicians Clinician Investigator Program to T.N. ",
year = "2009",
month = may,
day = "5",
doi = "10.1016/j.ccr.2009.03.017",
language = "English (US)",
volume = "15",
pages = "402--415",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",
}