Abstract
Growth-associated protein (GAP)-43 is highly expressed in neuronal growth cones during periods of axonal outgrowth in development and regeneration of the nervous system. Although GAP-43 is generally considered to be neuron-specific, it is also expressed in some glial cells of the peripheral and central nervous systems and in at least two populations of mesodermally-derived cells in the developing chick limb. GAP-43 mRNA is expressed transiently in developing limbs; although this expression is correlated temporally with the ingrowth of neurites and axons to the limbs, it appears to be independent of nerves. Immunoreactivity for GAP-43 colocalizes in some developing limb muscle and GAP-43 mRNA and protein are particularly abundant in the interdigital mesenchyme that undergoes programmed cell death. GAP-43 has been postulated to mediate rapid changes in cell shape in neurons and glial cells and may serve a similar function in myoblasts fusing to form myotubes and in apototic and phagocytic cells of the interdigital mesenchyme.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 599-609 |
| Number of pages | 11 |
| Journal | Progress in Clinical and Biological Research |
| Volume | 383 B |
| State | Published - 1993 |
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Transient expression of GAP-43 in nonneuronal cells of the embryonic chick limb. / Stocker, K. M.; Baizer, L.; Ciment, Gary.
In: Progress in Clinical and Biological Research, Vol. 383 B, 1993, p. 599-609.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transient expression of GAP-43 in nonneuronal cells of the embryonic chick limb.
AU - Stocker, K. M.
AU - Baizer, L.
AU - Ciment, Gary
PY - 1993
Y1 - 1993
N2 - Growth-associated protein (GAP)-43 is highly expressed in neuronal growth cones during periods of axonal outgrowth in development and regeneration of the nervous system. Although GAP-43 is generally considered to be neuron-specific, it is also expressed in some glial cells of the peripheral and central nervous systems and in at least two populations of mesodermally-derived cells in the developing chick limb. GAP-43 mRNA is expressed transiently in developing limbs; although this expression is correlated temporally with the ingrowth of neurites and axons to the limbs, it appears to be independent of nerves. Immunoreactivity for GAP-43 colocalizes in some developing limb muscle and GAP-43 mRNA and protein are particularly abundant in the interdigital mesenchyme that undergoes programmed cell death. GAP-43 has been postulated to mediate rapid changes in cell shape in neurons and glial cells and may serve a similar function in myoblasts fusing to form myotubes and in apototic and phagocytic cells of the interdigital mesenchyme.
AB - Growth-associated protein (GAP)-43 is highly expressed in neuronal growth cones during periods of axonal outgrowth in development and regeneration of the nervous system. Although GAP-43 is generally considered to be neuron-specific, it is also expressed in some glial cells of the peripheral and central nervous systems and in at least two populations of mesodermally-derived cells in the developing chick limb. GAP-43 mRNA is expressed transiently in developing limbs; although this expression is correlated temporally with the ingrowth of neurites and axons to the limbs, it appears to be independent of nerves. Immunoreactivity for GAP-43 colocalizes in some developing limb muscle and GAP-43 mRNA and protein are particularly abundant in the interdigital mesenchyme that undergoes programmed cell death. GAP-43 has been postulated to mediate rapid changes in cell shape in neurons and glial cells and may serve a similar function in myoblasts fusing to form myotubes and in apototic and phagocytic cells of the interdigital mesenchyme.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027712160&partnerID=8YFLogxK
M3 - Article
C2 - 8115376
AN - SCOPUS:0027712160
VL - 383 B
SP - 599
EP - 609
JO - Progress in Clinical and Biological Research
JF - Progress in Clinical and Biological Research
SN - 0361-7742
ER -