Transient expression of GAP-43 in nonneuronal cells of the embryonic chick limb.

K. M. Stocker, L. Baizer, Gary Ciment

Research output: Contribution to journalArticle

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Abstract

Growth-associated protein (GAP)-43 is highly expressed in neuronal growth cones during periods of axonal outgrowth in development and regeneration of the nervous system. Although GAP-43 is generally considered to be neuron-specific, it is also expressed in some glial cells of the peripheral and central nervous systems and in at least two populations of mesodermally-derived cells in the developing chick limb. GAP-43 mRNA is expressed transiently in developing limbs; although this expression is correlated temporally with the ingrowth of neurites and axons to the limbs, it appears to be independent of nerves. Immunoreactivity for GAP-43 colocalizes in some developing limb muscle and GAP-43 mRNA and protein are particularly abundant in the interdigital mesenchyme that undergoes programmed cell death. GAP-43 has been postulated to mediate rapid changes in cell shape in neurons and glial cells and may serve a similar function in myoblasts fusing to form myotubes and in apototic and phagocytic cells of the interdigital mesenchyme.

Original languageEnglish (US)
Pages (from-to)599-609
Number of pages11
JournalProgress in Clinical and Biological Research
Volume383 B
StatePublished - 1993

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GAP-43 Protein
Extremities
Mesoderm
Neuroglia
Neurons
Growth Cones
Messenger RNA
Cell Shape
Myoblasts
Skeletal Muscle Fibers
Peripheral Nervous System
Neurites
Phagocytes
Nervous System
Axons
Regeneration
Cell Death
Central Nervous System
Muscles
Population

ASJC Scopus subject areas

  • Medicine(all)

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Transient expression of GAP-43 in nonneuronal cells of the embryonic chick limb. / Stocker, K. M.; Baizer, L.; Ciment, Gary.

In: Progress in Clinical and Biological Research, Vol. 383 B, 1993, p. 599-609.

Research output: Contribution to journalArticle

Stocker, K. M. ; Baizer, L. ; Ciment, Gary. / Transient expression of GAP-43 in nonneuronal cells of the embryonic chick limb. In: Progress in Clinical and Biological Research. 1993 ; Vol. 383 B. pp. 599-609.
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