Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice

Xavier Gallego, Jessica Ruiz-Medina, Olga Valverde, Susanna Molas, Noemí Robles, Josefa Sabrià, John Jr Crabbe, Mara Dierssen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Abuse of alcohol and smoking are extensively co-morbid. Some studies suggest partial commonality of action of alcohol and nicotine mediated through nicotinic acetylcholine receptors (nAChRs). We tested mice with transgenic over expression of the alpha 5, alpha 3, beta 4 receptor subunit genes, which lie in a cluster on human chromosome 15, that were previously shown to have increased nicotine self-administration, for several responses to ethanol. Transgenic and wild-type mice did not differ in sensitivity to several acute behavioral responses to ethanol. However, transgenic mice drank less ethanol than wild-type in a two-bottle (ethanol vs. water) preference test. These results suggest a complex role for this receptor subunit gene cluster in the modulation of ethanol's as well as nicotine's effects.

Original languageEnglish (US)
Pages (from-to)205-215
Number of pages11
JournalAlcohol
Volume46
Issue number3
DOIs
StatePublished - May 2012

Fingerprint

Nicotinic Receptors
nicotine
Ethanol
Genes
Nicotine
Transgenic Mice
alcohol
self-administration
Alcohols
smoking
abuse
Chromosomes, Human, Pair 15
Self Administration
Bottles
Human Chromosomes
water
Chromosomes
Multigene Family
Alcoholism
Smoking

Keywords

  • Dependence
  • Ethanol
  • NAChR subunits
  • Nicotine
  • Preference drinking
  • Transgenic mice

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neurology
  • Toxicology
  • Health(social science)

Cite this

Gallego, X., Ruiz-Medina, J., Valverde, O., Molas, S., Robles, N., Sabrià, J., ... Dierssen, M. (2012). Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. Alcohol, 46(3), 205-215. https://doi.org/10.1016/j.alcohol.2011.11.005

Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. / Gallego, Xavier; Ruiz-Medina, Jessica; Valverde, Olga; Molas, Susanna; Robles, Noemí; Sabrià, Josefa; Crabbe, John Jr; Dierssen, Mara.

In: Alcohol, Vol. 46, No. 3, 05.2012, p. 205-215.

Research output: Contribution to journalArticle

Gallego, X, Ruiz-Medina, J, Valverde, O, Molas, S, Robles, N, Sabrià, J, Crabbe, JJ & Dierssen, M 2012, 'Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice', Alcohol, vol. 46, no. 3, pp. 205-215. https://doi.org/10.1016/j.alcohol.2011.11.005
Gallego, Xavier ; Ruiz-Medina, Jessica ; Valverde, Olga ; Molas, Susanna ; Robles, Noemí ; Sabrià, Josefa ; Crabbe, John Jr ; Dierssen, Mara. / Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. In: Alcohol. 2012 ; Vol. 46, No. 3. pp. 205-215.
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