Transforming growth factor-α gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation

Ying Jun Ma, Marie Pierre Junier, Maria E. Costa, Sergio R. Ojeda

    Research output: Contribution to journalArticle

    177 Scopus citations

    Abstract

    Hypothalamic injury causes female sexual precocity by activating luteinizing hormone-releasing hormone (LHRH) neurons, which control sexual development. Transforming growth factor-α (TGF-α) has been implicated in this process, but its involvement in normal sexual maturation is unknown. The present study addresses this issue. TGF-α mRNA and protein were found mostly in astroglia, in regions of the hypothalamus concerned with LHRH control. Hypothalamic TGF-α mRNA levels increased at times when secretion of pituitary gonadotropins-an LHRH-dependent event-was elevated, particularly at the time of puberty. Gonadal steroids involved in the control of LHRH secretion increased TGF-α mRNA levels. Blockade of TGF-α action in the median eminence, a site of glial-LHRH nerve terminal association, delayed puberty. These results suggest that TGF-α of glial origin is a component of the developmental program by which the brain controls mammalian sexual maturation.

    Original languageEnglish (US)
    Pages (from-to)657-670
    Number of pages14
    JournalNeuron
    Volume9
    Issue number4
    DOIs
    StatePublished - Oct 1992

    ASJC Scopus subject areas

    • Neuroscience(all)

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