Transforming growth factor-α gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation

Ying Jun Ma, Marie Pierre Junier, Maria E. Costa, Sergio Ojeda

    Research output: Contribution to journalArticle

    176 Citations (Scopus)

    Abstract

    Hypothalamic injury causes female sexual precocity by activating luteinizing hormone-releasing hormone (LHRH) neurons, which control sexual development. Transforming growth factor-α (TGF-α) has been implicated in this process, but its involvement in normal sexual maturation is unknown. The present study addresses this issue. TGF-α mRNA and protein were found mostly in astroglia, in regions of the hypothalamus concerned with LHRH control. Hypothalamic TGF-α mRNA levels increased at times when secretion of pituitary gonadotropins-an LHRH-dependent event-was elevated, particularly at the time of puberty. Gonadal steroids involved in the control of LHRH secretion increased TGF-α mRNA levels. Blockade of TGF-α action in the median eminence, a site of glial-LHRH nerve terminal association, delayed puberty. These results suggest that TGF-α of glial origin is a component of the developmental program by which the brain controls mammalian sexual maturation.

    Original languageEnglish (US)
    Pages (from-to)657-670
    Number of pages14
    JournalNeuron
    Volume9
    Issue number4
    DOIs
    StatePublished - 1992

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    Sexual Maturation
    Transforming Growth Factors
    Hypothalamus
    Gonadotropin-Releasing Hormone
    Gene Expression
    Neuroglia
    Messenger RNA
    Delayed Puberty
    Pituitary Gonadotropins
    Median Eminence
    Sexual Development
    Puberty
    Astrocytes
    Steroids
    Neurons
    Wounds and Injuries
    Brain
    Proteins

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Transforming growth factor-α gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation. / Jun Ma, Ying; Junier, Marie Pierre; Costa, Maria E.; Ojeda, Sergio.

    In: Neuron, Vol. 9, No. 4, 1992, p. 657-670.

    Research output: Contribution to journalArticle

    Jun Ma, Ying ; Junier, Marie Pierre ; Costa, Maria E. ; Ojeda, Sergio. / Transforming growth factor-α gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation. In: Neuron. 1992 ; Vol. 9, No. 4. pp. 657-670.
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