TY - JOUR
T1 - Transforming dysfunctional CD8+ T cells into natural controller–like CD8+ T cells
T2 - can TCF-1 be the magic wand?
AU - Takata, Hiroshi
AU - Trautmann, Lydie
N1 - Funding Information:
This publication was made possible with support from the NIH (R01MH106466 and R01AI147749) and the Oregon National Primate Research Center (P51 OD011092). The opinions or assertions contained herein are the private views of the authors and are not to be construed as official, or as reflecting true views of the NIH.
Publisher Copyright:
© 2022, Takata et al.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - HIV infection results in defective CD8+ T cell functions that are incompletely resolved by antiretroviral therapy (ART) except in natural controllers, who have functional CD8+ T cells associated with viral control. In this issue of the JCI, Perdomo-Celis et al. demonstrated that targeting the Wnt/transcription factor T cell factor 1 (Wnt/TCF-1) pathway in dysfunctional CD8+ T cells led to gains in stemness phenotype, metabolic quiescence, survival potential, response to homeostatic γ-chain cytokines, and antiviral capacities, similar to profiles of functional CD8+ T cells in natural controllers. Although reprogramming might not sufficiently reverse the imprinted dysfunction of CD8+ T cells in HIV infection, these findings outline the Wnt/TCF-1 pathway as a potential target to reprogram dysfunctional CD8+ T cells in efforts to achieve HIV remission.
AB - HIV infection results in defective CD8+ T cell functions that are incompletely resolved by antiretroviral therapy (ART) except in natural controllers, who have functional CD8+ T cells associated with viral control. In this issue of the JCI, Perdomo-Celis et al. demonstrated that targeting the Wnt/transcription factor T cell factor 1 (Wnt/TCF-1) pathway in dysfunctional CD8+ T cells led to gains in stemness phenotype, metabolic quiescence, survival potential, response to homeostatic γ-chain cytokines, and antiviral capacities, similar to profiles of functional CD8+ T cells in natural controllers. Although reprogramming might not sufficiently reverse the imprinted dysfunction of CD8+ T cells in HIV infection, these findings outline the Wnt/TCF-1 pathway as a potential target to reprogram dysfunctional CD8+ T cells in efforts to achieve HIV remission.
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U2 - 10.1172/JCI160474
DO - 10.1172/JCI160474
M3 - Review article
C2 - 35642630
AN - SCOPUS:85131226482
SN - 0021-9738
VL - 132
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 11
M1 - e160474
ER -