@article{245747b905364bb9a55d0d882573cd22,
title = "Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1",
abstract = "Transformation of myoblasts by activated ras inhibits myogenic differentiation. We demonstrate that this oncogene inhibits expression of the muscle regulatory factors MyoD1 and myogenin. Expression of retroviral-encoded MyoD1 in ras-transformed myoblasts leads to the re-expression of both terminal differentiation markers and lineage markers expressed in proliferating myoblasts (including endogenous MyoD1 and myogenin), suggesting that ras inhibits myogenic differentiation in a manner dependent on the loss of MyoD1 expression. In addition, we show that fos transformation of myoblasts inhibits muscle differentiation by a similar mechanism.",
author = "Lassar, {Andrew B.} and Thayer, {Mathew J.} and Overell, {Robert W.} and Harold Weintraub",
note = "Funding Information: We thank Pritinder Kaur for kindly setting up the growth in soft agarose assay, Pei-Feng Cheng for excellent technical assistance, Lauretta Clark for assistance with Y2 ceil culture, Helen Blau for C2C12 cells, Hans Bloemendai, Steve Haushka, Douglas Lowy, John Merlie, Helmut Ponta, lnder Verma, and Woody Wright for plasmids. Mohammed Adam and Dusty Miller for providing us with the high titer MyoDl retrovirus, H. L. S. and R. P M. for encouragement, and our colleagues at the Hutchinson Center for their thoughtful comments on the manuscript. A. B. L. is a Lucille P Markey scholar, and this work was supported in part by a grant from the Lucille I? Markey Charitable Trust and by a grant to H. W. from the National Institutes of Health.",
year = "1989",
month = aug,
day = "25",
doi = "10.1016/0092-8674(89)90101-3",
language = "English (US)",
volume = "58",
pages = "659--667",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",
}