Transendoscopic intraoperative recording of gelastic seizures from a hypothalamic hamartoma

Colin Roberts, Eric M. Thompson, Nathan Selden

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Object: The differential diagnosis of hypothalamic masses in children includes hamartomas, which are associated with gelastic seizures and endocrine dysfunction. The purpose of this study was to utilize transendoscopic electroencephalography (EEG) recording at the time of tissue biopsy to further assist in diagnosis, determination of prognosis, and treatment planning. Methods: We present the case of an infant with gelastic seizures and a large hypothalamic mass lesion. Despite a clinical and radiographic presentation typical of hypothalamic hamartoma (HH), slight growth on serial imaging raised concern for a diagnosis of intrinsic neoplasm. Biopsy of the lesion was recommended. Results: Transventricular, endoscopic biopsy, was undertaken, with concurrent intraoperative, transendoscopic EEG recording using a standard epilepsy depth recording macroelectrode. Numerous electrographic seizures were recorded. Histopathology revealed a HH. Conclusion: This is the first report of intraoperative macroelectrode recording of electrographic seizures transendoscopically from a HH. This technique may prove useful for diagnosis, prognosis and treatment planning, as well as to guide transendoscopic therapeutic interventions for HH.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalPediatric Neurosurgery
Volume47
Issue number2
DOIs
StatePublished - Oct 2011

Fingerprint

Laughter
Seizures
Biopsy
Electroencephalography
Hamartoma
Epilepsy
Differential Diagnosis
Therapeutics
Hypothalamic hamartomas
Growth
Neoplasms

Keywords

  • Depth electrodes
  • Gelastic epilepsy
  • Hypothalamic hamartoma
  • Neuroendoscopy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology
  • Surgery

Cite this

Transendoscopic intraoperative recording of gelastic seizures from a hypothalamic hamartoma. / Roberts, Colin; Thompson, Eric M.; Selden, Nathan.

In: Pediatric Neurosurgery, Vol. 47, No. 2, 10.2011, p. 147-151.

Research output: Contribution to journalArticle

@article{4d67d209a5344d55b72dd12aa70a5795,
title = "Transendoscopic intraoperative recording of gelastic seizures from a hypothalamic hamartoma",
abstract = "Object: The differential diagnosis of hypothalamic masses in children includes hamartomas, which are associated with gelastic seizures and endocrine dysfunction. The purpose of this study was to utilize transendoscopic electroencephalography (EEG) recording at the time of tissue biopsy to further assist in diagnosis, determination of prognosis, and treatment planning. Methods: We present the case of an infant with gelastic seizures and a large hypothalamic mass lesion. Despite a clinical and radiographic presentation typical of hypothalamic hamartoma (HH), slight growth on serial imaging raised concern for a diagnosis of intrinsic neoplasm. Biopsy of the lesion was recommended. Results: Transventricular, endoscopic biopsy, was undertaken, with concurrent intraoperative, transendoscopic EEG recording using a standard epilepsy depth recording macroelectrode. Numerous electrographic seizures were recorded. Histopathology revealed a HH. Conclusion: This is the first report of intraoperative macroelectrode recording of electrographic seizures transendoscopically from a HH. This technique may prove useful for diagnosis, prognosis and treatment planning, as well as to guide transendoscopic therapeutic interventions for HH.",
keywords = "Depth electrodes, Gelastic epilepsy, Hypothalamic hamartoma, Neuroendoscopy",
author = "Colin Roberts and Thompson, {Eric M.} and Nathan Selden",
year = "2011",
month = "10",
doi = "10.1159/000330547",
language = "English (US)",
volume = "47",
pages = "147--151",
journal = "Pediatric Neurosurgery",
issn = "1016-2291",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Transendoscopic intraoperative recording of gelastic seizures from a hypothalamic hamartoma

AU - Roberts, Colin

AU - Thompson, Eric M.

AU - Selden, Nathan

PY - 2011/10

Y1 - 2011/10

N2 - Object: The differential diagnosis of hypothalamic masses in children includes hamartomas, which are associated with gelastic seizures and endocrine dysfunction. The purpose of this study was to utilize transendoscopic electroencephalography (EEG) recording at the time of tissue biopsy to further assist in diagnosis, determination of prognosis, and treatment planning. Methods: We present the case of an infant with gelastic seizures and a large hypothalamic mass lesion. Despite a clinical and radiographic presentation typical of hypothalamic hamartoma (HH), slight growth on serial imaging raised concern for a diagnosis of intrinsic neoplasm. Biopsy of the lesion was recommended. Results: Transventricular, endoscopic biopsy, was undertaken, with concurrent intraoperative, transendoscopic EEG recording using a standard epilepsy depth recording macroelectrode. Numerous electrographic seizures were recorded. Histopathology revealed a HH. Conclusion: This is the first report of intraoperative macroelectrode recording of electrographic seizures transendoscopically from a HH. This technique may prove useful for diagnosis, prognosis and treatment planning, as well as to guide transendoscopic therapeutic interventions for HH.

AB - Object: The differential diagnosis of hypothalamic masses in children includes hamartomas, which are associated with gelastic seizures and endocrine dysfunction. The purpose of this study was to utilize transendoscopic electroencephalography (EEG) recording at the time of tissue biopsy to further assist in diagnosis, determination of prognosis, and treatment planning. Methods: We present the case of an infant with gelastic seizures and a large hypothalamic mass lesion. Despite a clinical and radiographic presentation typical of hypothalamic hamartoma (HH), slight growth on serial imaging raised concern for a diagnosis of intrinsic neoplasm. Biopsy of the lesion was recommended. Results: Transventricular, endoscopic biopsy, was undertaken, with concurrent intraoperative, transendoscopic EEG recording using a standard epilepsy depth recording macroelectrode. Numerous electrographic seizures were recorded. Histopathology revealed a HH. Conclusion: This is the first report of intraoperative macroelectrode recording of electrographic seizures transendoscopically from a HH. This technique may prove useful for diagnosis, prognosis and treatment planning, as well as to guide transendoscopic therapeutic interventions for HH.

KW - Depth electrodes

KW - Gelastic epilepsy

KW - Hypothalamic hamartoma

KW - Neuroendoscopy

UR - http://www.scopus.com/inward/record.url?scp=80054962622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054962622&partnerID=8YFLogxK

U2 - 10.1159/000330547

DO - 10.1159/000330547

M3 - Article

C2 - 21921578

AN - SCOPUS:80054962622

VL - 47

SP - 147

EP - 151

JO - Pediatric Neurosurgery

JF - Pediatric Neurosurgery

SN - 1016-2291

IS - 2

ER -