Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes

Shilpa Kadam; Beverly M. Emerson

doi:10.1016/S1097-2765(03)00034-0

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes

Shilpa Kadam, Beverly M. Emerson

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290 Scopus citations

Abstract

Mammalian SWI/SNF chromatin remodeling complexes are involved in critical aspects of cellular growth and genomic stability. Each complex contains one of two highly homologous ATPases, BRG1 and BRM, yet little is known about their specialized functions. We show that BRG1and BRM associate with different promoters during cellular proliferation and differentiation, and in response to specific signaling pathways by preferential interaction with certain classes of transcription factors. BRG1 binds to zinc finger proteins through a unique N-terminal domain that is not present in BRM. BRM interacts with two ankyrin repeat proteins that are critical components of Notch signal transduction. Thus, BRG1 and BRM complexes may direct distinct cellular processes by recruitment to specific promoters through protein-protein interactions that are unique to each ATPase.

Original language	English (US)
Pages (from-to)	377-389
Number of pages	13
Journal	Molecular Cell
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/S1097-2765(03)00034-0
State	Published - Feb 1 2003
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/S1097-2765(03)00034-0

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title = "Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes",

abstract = "Mammalian SWI/SNF chromatin remodeling complexes are involved in critical aspects of cellular growth and genomic stability. Each complex contains one of two highly homologous ATPases, BRG1 and BRM, yet little is known about their specialized functions. We show that BRG1and BRM associate with different promoters during cellular proliferation and differentiation, and in response to specific signaling pathways by preferential interaction with certain classes of transcription factors. BRG1 binds to zinc finger proteins through a unique N-terminal domain that is not present in BRM. BRM interacts with two ankyrin repeat proteins that are critical components of Notch signal transduction. Thus, BRG1 and BRM complexes may direct distinct cellular processes by recruitment to specific promoters through protein-protein interactions that are unique to each ATPase.",

author = "Shilpa Kadam and Emerson, {Beverly M.}",

note = "Funding Information: This paper is dedicated to Sunanda and Balkrishna Kadam. We thank Drs. Katherine Jones, Christy Fryer, Joaquin Espinosa, Ron Evans, Inder Verma, Mark Groudine, Gerry Weinmaster, Nikolai Timchencko, Gerd Blobel, and Weidong Wang for their generous gifts of reagents used in these studies. We also thank Gordon Pfeifer for his expert technical assistance. This work was supported by grants to B.M.E. from the National Institutes of Health, and we acknowledge the helpful services of the National Cell Culture Center.",

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doi = "10.1016/S1097-2765(03)00034-0",

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AU - Kadam, Shilpa

AU - Emerson, Beverly M.

N1 - Funding Information: This paper is dedicated to Sunanda and Balkrishna Kadam. We thank Drs. Katherine Jones, Christy Fryer, Joaquin Espinosa, Ron Evans, Inder Verma, Mark Groudine, Gerry Weinmaster, Nikolai Timchencko, Gerd Blobel, and Weidong Wang for their generous gifts of reagents used in these studies. We also thank Gordon Pfeifer for his expert technical assistance. This work was supported by grants to B.M.E. from the National Institutes of Health, and we acknowledge the helpful services of the National Cell Culture Center.

PY - 2003/2/1

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N2 - Mammalian SWI/SNF chromatin remodeling complexes are involved in critical aspects of cellular growth and genomic stability. Each complex contains one of two highly homologous ATPases, BRG1 and BRM, yet little is known about their specialized functions. We show that BRG1and BRM associate with different promoters during cellular proliferation and differentiation, and in response to specific signaling pathways by preferential interaction with certain classes of transcription factors. BRG1 binds to zinc finger proteins through a unique N-terminal domain that is not present in BRM. BRM interacts with two ankyrin repeat proteins that are critical components of Notch signal transduction. Thus, BRG1 and BRM complexes may direct distinct cellular processes by recruitment to specific promoters through protein-protein interactions that are unique to each ATPase.

AB - Mammalian SWI/SNF chromatin remodeling complexes are involved in critical aspects of cellular growth and genomic stability. Each complex contains one of two highly homologous ATPases, BRG1 and BRM, yet little is known about their specialized functions. We show that BRG1and BRM associate with different promoters during cellular proliferation and differentiation, and in response to specific signaling pathways by preferential interaction with certain classes of transcription factors. BRG1 binds to zinc finger proteins through a unique N-terminal domain that is not present in BRM. BRM interacts with two ankyrin repeat proteins that are critical components of Notch signal transduction. Thus, BRG1 and BRM complexes may direct distinct cellular processes by recruitment to specific promoters through protein-protein interactions that are unique to each ATPase.

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Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes

Abstract

ASJC Scopus subject areas

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