Transcriptional regulation of the Bacillus subtilis menp1 promoter

Xuan Qin, Harry W. Taber

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The Bacillus subtilis men genes encode biosynthetic enzymes for formation of the respiratory chain component menaquinone. The menp1 promoter previously was shown to be the primary cis element for menFD gene expression. In the present work, it was found that either supplementation with nonfermentable carbon sources or reutilization of glycolytic end products increased menp1 activity in the late postexponential phase. The effect on menp1 activity by a particular end product (such as acetoin or acetate) was prevented by blocking the corresponding pathway for end product utilization. Alteration of a TGAAA motif within the promoter region resulted in unregulated menp1 activity throughout the culture cycle, irrespective of the carbon source added.

Original languageEnglish (US)
Pages (from-to)705-713
Number of pages9
JournalJournal of bacteriology
Volume178
Issue number3
DOIs
StatePublished - Feb 1996
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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