Transcriptional regulation and specification of neural stem cells

Kimberly J. Christie, Ben Emery, Mark Denham, Helena Bujalka, Holly S. Cate, Ann M. Turnley

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

With the discovery two decades ago that the adult brain contains neural stem cells (NSCs) capable of producing new neurons, a great deal of research has been undertaken to manipulate these cells to repair the damaged nervous system. Much progress has been made in understanding what regulates adult neural stem cell specification, proliferation and differentiation but much remains to be determined. Lessons can be learned from understanding how embryonic neural stem cells produce the exquisitely complicated organ that is the adult mammalian nervous system. This review will highlight the role of transcriptional regulation of mammalian neural stem cells during embryonic development and compare these to the adult neural stem cell/neural precursor cell (NPC) niches of the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus. Normal physiological NSC/NPC regulation will be explored, as well as their regulation and responses following neural injury and disease. Finally, transcriptional regulation of the endogenous NSC/NPCs will be compared and contrasted with embryonic stem/induced pluripotent stem (ES/iPS) cell-derived NSC/NPCs. Recapitulation of the embryonic sequence of transcriptional events in neural stem cell development into specific neuronal or glial lineages improves directed differentiation of ES/iPS cells and may be useful for activation and specification of endogenous adult neural stem cells for therapeutic purposes.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages129-155
Number of pages27
Volume786
ISBN (Print)9789400766204
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume786
ISSN (Print)00652598

Fingerprint

Neural Stem Cells
Stem cells
Specifications
Adult Stem Cells
Induced Pluripotent Stem Cells
Lateral Ventricles
Nervous System
Neurology
Parahippocampal Gyrus
Dentate Gyrus
Embryonic Stem Cells
Neuroglia
Embryonic Development
Cell Differentiation
Neurons
Cell Proliferation
Brain
Repair
Chemical activation

Keywords

  • Gliogenesis
  • Neural progenitor cell
  • Neural stem cell
  • Neurogenesis
  • Transcriptional regulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Christie, K. J., Emery, B., Denham, M., Bujalka, H., Cate, H. S., & Turnley, A. M. (2013). Transcriptional regulation and specification of neural stem cells. In Advances in Experimental Medicine and Biology (Vol. 786, pp. 129-155). (Advances in Experimental Medicine and Biology; Vol. 786). Springer New York LLC. https://doi.org/10.1007/978-94-7-6621-1_8

Transcriptional regulation and specification of neural stem cells. / Christie, Kimberly J.; Emery, Ben; Denham, Mark; Bujalka, Helena; Cate, Holly S.; Turnley, Ann M.

Advances in Experimental Medicine and Biology. Vol. 786 Springer New York LLC, 2013. p. 129-155 (Advances in Experimental Medicine and Biology; Vol. 786).

Research output: Chapter in Book/Report/Conference proceedingChapter

Christie, KJ, Emery, B, Denham, M, Bujalka, H, Cate, HS & Turnley, AM 2013, Transcriptional regulation and specification of neural stem cells. in Advances in Experimental Medicine and Biology. vol. 786, Advances in Experimental Medicine and Biology, vol. 786, Springer New York LLC, pp. 129-155. https://doi.org/10.1007/978-94-7-6621-1_8
Christie KJ, Emery B, Denham M, Bujalka H, Cate HS, Turnley AM. Transcriptional regulation and specification of neural stem cells. In Advances in Experimental Medicine and Biology. Vol. 786. Springer New York LLC. 2013. p. 129-155. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-94-7-6621-1_8
Christie, Kimberly J. ; Emery, Ben ; Denham, Mark ; Bujalka, Helena ; Cate, Holly S. ; Turnley, Ann M. / Transcriptional regulation and specification of neural stem cells. Advances in Experimental Medicine and Biology. Vol. 786 Springer New York LLC, 2013. pp. 129-155 (Advances in Experimental Medicine and Biology).
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