@article{c289d6a47d1e4ce2b4db7514a0896017,
title = "Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution",
abstract = "Messmer et al. demonstrate that the single-cell transcriptomes of naive and primed human embryonic stem cells (hESCs) are mostly homogeneous. The study defines an expression signature that is conserved across species and shows differential epigenetic regulation between naive and primed pluripotency.",
keywords = "early embryonic development, evolution, heterogeneity, human embryonic stem cells, naive, pluripotency, primed, single-cell RNA-seq",
author = "Tobias Messmer and {von Meyenn}, Ferdinand and Aurora Savino and F{\'a}tima Santos and Hisham Mohammed and Lun, {Aaron Tin Long} and Marioni, {John C.} and Wolf Reik",
note = "Funding Information: We are grateful to members of the Marioni and Reik lab for helpful discussions. We would like to thank Amanda J. Collier for maintaining hESC cultures. We thank the WT Sanger sequencing facility for assistance with high-throughput sequencing. The work was supported by core funding from Cancer Research UK (award 17197 to J.C.M.), EMBL (to J.C.M.), an UKRI Rutherford Fund Fellowship (to F.v.M.), BBSRC ( BB/K010867/1 to W.R.), and the Wellcome Trust ( 095645/Z/11/Z to W.R.). Publisher Copyright: {\textcopyright} 2019 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = jan,
day = "22",
doi = "10.1016/j.celrep.2018.12.099",
language = "English (US)",
volume = "26",
pages = "815--824.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",
}