Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution

Tobias Messmer, Ferdinand von Meyenn, Aurora Savino, Fátima Santos, Hisham Mohammed, Aaron Tin Long Lun, John C. Marioni, Wolf Reik

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Messmer et al. demonstrate that the single-cell transcriptomes of naive and primed human embryonic stem cells (hESCs) are mostly homogeneous. The study defines an expression signature that is conserved across species and shows differential epigenetic regulation between naive and primed pluripotency.

Original languageEnglish (US)
Pages (from-to)815-824.e4
JournalCell Reports
Volume26
Issue number4
DOIs
StatePublished - Jan 22 2019
Externally publishedYes

Keywords

  • early embryonic development
  • evolution
  • heterogeneity
  • human embryonic stem cells
  • naive
  • pluripotency
  • primed
  • single-cell RNA-seq

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution'. Together they form a unique fingerprint.

Cite this