Messmer et al. demonstrate that the single-cell transcriptomes of naive and primed human embryonic stem cells (hESCs) are mostly homogeneous. The study defines an expression signature that is conserved across species and shows differential epigenetic regulation between naive and primed pluripotency.
- early embryonic development
- human embryonic stem cells
- single-cell RNA-seq
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)