Transcriptional coregulators of the nuclear receptor superfamily: Coactivators and corepressors

J. W. Lee, Y. C. Lee, S. Y. Na, D. Ju Jung, S. K. Lee

Research output: Contribution to journalReview article

114 Scopus citations

Abstract

Nuclear receptors, many of which undergo a major conformational change upon binding specific ligand, belong to a superfamily of proteins that bind to specific DNA sequences and control gene transcription. They regulate the assembly of a transcriptional preinitiation complex at the promoter of target genes and modulate their expression in response to ligand. In particular, nuclear receptors repress or stimulate transcription by recruiting corepressor or coactivator proteins, in addition to directly contacting the basal transcription machinery. In this review, we discuss recent progress in studies of these transcriptional coregulators of nuclear receptors.

Original languageEnglish (US)
Pages (from-to)289-297
Number of pages9
JournalCellular and Molecular Life Sciences
Volume58
Issue number2
DOIs
StatePublished - Jan 1 2001

Keywords

  • Coactivator
  • Corepressor
  • Nuclear receptor
  • Transcription

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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