Abstract
Background: Identifying characteristics associated with transcranial magnetic stimulation (TMS) benefit would offer insight as to why some individuals experience tinnitus relief following TMS treatment, whereas others do not. The purpose of this study was to use the Tinnitus Functional Index (TFI) and its subscales to identify specific factors associated with TMS treatment responsiveness. Methods: Individuals with bothersome tinnitus underwent 2000 pulses of 1-Hz TMS for 10 consecutive business days. The primary outcome measure was the TFI which yields a total score and eight individual subscale scores. Analyses were performed on baseline data from the active arm (n = 35) of a prospective, double-blind, randomized placebo-controlled clinical trial of TMS for tinnitus. Results: Baseline total TFI score and three of the eight TFI subscales were useful in differentiating between responders and nonresponders to TMS intervention for tinnitus. These findings are not definitive, but suggest potential factors that contribute to perceived benefit following TMS. Conclusions: Overall, the main factor associated with TMS benefit was a higher tinnitus severity score for responders at baseline. The TFI subscales helped to clarify the factors that contributed to a higher severity score at baseline. Large-scale prospective research using systematic approaches is needed to identify and describe additional factors associated with tinnitus benefit following TMS. Trial registration: ClinicalTrials.gov, ID: NCT01104207. Registered on 13 April 2010.
| Original language | English (US) |
|---|---|
| Article number | 64 |
| Journal | Trials |
| Volume | 18 |
| Issue number | 1 |
| DOIs |
|
| State | Published - Feb 9 2017 |
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Keywords
- Questionnaire
- Tinnitus
- Transcranial magnetic stimulation
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Pharmacology (medical)
Cite this
Transcranial magnetic stimulation for tinnitus : Using the Tinnitus Functional Index to predict benefit in a randomized controlled trial. / Theodoroff, Sarah; Griest, Susan; Folmer, Robert L.
In: Trials, Vol. 18, No. 1, 64, 09.02.2017.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - Transcranial magnetic stimulation for tinnitus
T2 - Using the Tinnitus Functional Index to predict benefit in a randomized controlled trial
AU - Theodoroff, Sarah
AU - Griest, Susan
AU - Folmer, Robert L.
PY - 2017/2/9
Y1 - 2017/2/9
N2 - Background: Identifying characteristics associated with transcranial magnetic stimulation (TMS) benefit would offer insight as to why some individuals experience tinnitus relief following TMS treatment, whereas others do not. The purpose of this study was to use the Tinnitus Functional Index (TFI) and its subscales to identify specific factors associated with TMS treatment responsiveness. Methods: Individuals with bothersome tinnitus underwent 2000 pulses of 1-Hz TMS for 10 consecutive business days. The primary outcome measure was the TFI which yields a total score and eight individual subscale scores. Analyses were performed on baseline data from the active arm (n = 35) of a prospective, double-blind, randomized placebo-controlled clinical trial of TMS for tinnitus. Results: Baseline total TFI score and three of the eight TFI subscales were useful in differentiating between responders and nonresponders to TMS intervention for tinnitus. These findings are not definitive, but suggest potential factors that contribute to perceived benefit following TMS. Conclusions: Overall, the main factor associated with TMS benefit was a higher tinnitus severity score for responders at baseline. The TFI subscales helped to clarify the factors that contributed to a higher severity score at baseline. Large-scale prospective research using systematic approaches is needed to identify and describe additional factors associated with tinnitus benefit following TMS. Trial registration: ClinicalTrials.gov, ID: NCT01104207. Registered on 13 April 2010.
AB - Background: Identifying characteristics associated with transcranial magnetic stimulation (TMS) benefit would offer insight as to why some individuals experience tinnitus relief following TMS treatment, whereas others do not. The purpose of this study was to use the Tinnitus Functional Index (TFI) and its subscales to identify specific factors associated with TMS treatment responsiveness. Methods: Individuals with bothersome tinnitus underwent 2000 pulses of 1-Hz TMS for 10 consecutive business days. The primary outcome measure was the TFI which yields a total score and eight individual subscale scores. Analyses were performed on baseline data from the active arm (n = 35) of a prospective, double-blind, randomized placebo-controlled clinical trial of TMS for tinnitus. Results: Baseline total TFI score and three of the eight TFI subscales were useful in differentiating between responders and nonresponders to TMS intervention for tinnitus. These findings are not definitive, but suggest potential factors that contribute to perceived benefit following TMS. Conclusions: Overall, the main factor associated with TMS benefit was a higher tinnitus severity score for responders at baseline. The TFI subscales helped to clarify the factors that contributed to a higher severity score at baseline. Large-scale prospective research using systematic approaches is needed to identify and describe additional factors associated with tinnitus benefit following TMS. Trial registration: ClinicalTrials.gov, ID: NCT01104207. Registered on 13 April 2010.
KW - Questionnaire
KW - Tinnitus
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=85012106592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85012106592&partnerID=8YFLogxK
U2 - 10.1186/s13063-017-1807-9
DO - 10.1186/s13063-017-1807-9
M3 - Comment/debate
C2 - 28183355
AN - SCOPUS:85012106592
VL - 18
JO - Trials
JF - Trials
SN - 1745-6215
IS - 1
M1 - 64
ER -