Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain

Nathan Selden, Darren R. Gitelman, Noriko Salamon-Murayama, Todd B. Parrish, M. Marsel Mesulam

Research output: Contribution to journalArticle

395 Citations (Scopus)

Abstract

All sectors of the human cerebral cortex receive dense cholinergic input. The origin of this projection is located in the Ch4 cell group of the nucleus basalis of Meynert. However, very little is known about the location of the pathways which link the cholinergic neurons of the nucleus basalis to the human cerebral cortex. This question was addressed in whole-hemisphere sections processed for the visualization of multiple cholinergic markers. Two highly organized and discrete bundles of cholinergic fibres extended from the nucleus basalis to the cerebral cortex and amygdala and were designated as the medial and lateral cholinergic pathways. These bundles contained acetylcholinesterase, choline acetyltransferase and nerve growth factor receptors, confirming their cholinergic nature and origin within the basal forebrain. The medial pathway joined the white matter of the gyrus rectus, curved around the rostrum of the corpus callosum to enter the cingulum and merged with fibres of the lateral pathway within the occipital lobe. It supplied the parolfactory, cingulate, pericingulate and retrosplenial cortices. The lateral pathway was subdivided into a capsular division travelling in the white matter of the external capsule and uncinate fasciculus and a perisylvian division travelling within the claustrum. Branches of the perisylvian division supplied the frontoparietal operculum, insula and superior temporal gyrus. Branches of the capsular division innervated the remaining parts of the frontal, parietal and temporal neocortex. Representation of these cholinergic pathways within a 3D MRI volume helped to identify white matter lesion sites that could interfere with the corticopetal flow of cholinergic pathways.

Original languageEnglish (US)
Pages (from-to)2249-2257
Number of pages9
JournalBrain
Volume121
Issue number12
StatePublished - 1998
Externally publishedYes

Fingerprint

Cerebrum
Cholinergic Agents
Brain
Cerebral Cortex
Cholinergic Fibers
Basal Nucleus of Meynert
Nerve Growth Factor Receptors
Occipital Lobe
Cholinergic Neurons
Choline O-Acetyltransferase
Corpus Callosum
Neocortex
Temporal Lobe
Acetylcholinesterase
Amygdala
Basal Ganglia
Prefrontal Cortex
Cell Nucleus
White Matter

Keywords

  • Acetylcholinesterase
  • Cerebral hemispheres
  • Choline acetyltransferase
  • Nerve growth factor receptor
  • Nucleus basalis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Selden, N., Gitelman, D. R., Salamon-Murayama, N., Parrish, T. B., & Mesulam, M. M. (1998). Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain, 121(12), 2249-2257.

Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. / Selden, Nathan; Gitelman, Darren R.; Salamon-Murayama, Noriko; Parrish, Todd B.; Mesulam, M. Marsel.

In: Brain, Vol. 121, No. 12, 1998, p. 2249-2257.

Research output: Contribution to journalArticle

Selden, N, Gitelman, DR, Salamon-Murayama, N, Parrish, TB & Mesulam, MM 1998, 'Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain', Brain, vol. 121, no. 12, pp. 2249-2257.
Selden N, Gitelman DR, Salamon-Murayama N, Parrish TB, Mesulam MM. Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain. 1998;121(12):2249-2257.
Selden, Nathan ; Gitelman, Darren R. ; Salamon-Murayama, Noriko ; Parrish, Todd B. ; Mesulam, M. Marsel. / Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. In: Brain. 1998 ; Vol. 121, No. 12. pp. 2249-2257.
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