Traditional smallpox vaccination with reduced risk of inadvertent contact spread by administration of povidone iodine ointment

Erika Hammarlund, Matthew W. Lewis, Jon M. Hanifin, Eric L. Simpson, Nichole E. Carlson, Mark K. Slifka

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

One concern with traditional smallpox vaccination is inadvertent spread of virus to atopic or immunocompromised contacts. To reduce this risk, we tested the ability of povidone iodine to inactivate infectious virus at the vaccination site beginning at 7 days after transcutaneous smallpox vaccination. This ointment rapidly inactivated virus on the skin without reducing neutralizing antibody titers or antiviral T cell responses. Moreover, there was no delay in healing/eschar separation following povidone iodine application. Together, this indicates that administration of an antiviral/antimicrobial cream can effectively block virus shedding after traditional smallpox vaccination and reduce the risks of autoinoculation or contact spread.

Original languageEnglish (US)
Pages (from-to)430-439
Number of pages10
JournalVaccine
Volume26
Issue number3
DOIs
StatePublished - Jan 17 2008

Keywords

  • Povidone iodine ointment
  • Smallpox vaccination
  • Vaccinia

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Traditional smallpox vaccination with reduced risk of inadvertent contact spread by administration of povidone iodine ointment'. Together they form a unique fingerprint.

  • Cite this