Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors

Lothar Lindemann, Martin Ebeling, Nicole A. Kratochwil, James R. Bunzow, David Grandy, Marius C. Hoener

    Research output: Contribution to journalArticle

    180 Citations (Scopus)

    Abstract

    Trace amines are endogenous compounds structurally related to classical biogenic amines that have been studied for decades, triggered by their link to psychiatric conditions of high epidemiological and economical relevance. The understanding of their pharmacology on the molecular level was hampered until the recent discovery of trace-amine-specific receptors. We completed the identification of all members of this novel GPCR family in human, chimpanzee, rat, and mouse and observed remarkable interspecies differences, even between human and chimpanzee. The analysis of the chromosomal localizations, phylogenetic relationships, and ligand pocket vectors reveals three distinct receptor subfamilies. As most of these receptors do not respond to trace amines, each subfamily will presumably have a distinct pharmacological profile, which remains to be identified. We propose a uniform nomenclature describing this novel GPCR family in all mammalian species as trace-amine-associated receptors (TAARs), which resolves the ambiguities and contradictions of the previous naming.

    Original languageEnglish (US)
    Pages (from-to)372-385
    Number of pages14
    JournalGenomics
    Volume85
    Issue number3
    DOIs
    StatePublished - Mar 2005

    Fingerprint

    G-Protein-Coupled Receptors
    Amines
    Pan troglodytes
    Pharmacology
    Biogenic Amines
    Terminology
    Psychiatry
    Ligands

    Keywords

    • Chimpanzee
    • GPCR
    • Nomenclature
    • Phylogeny
    • Trace amine

    ASJC Scopus subject areas

    • Genetics

    Cite this

    Lindemann, L., Ebeling, M., Kratochwil, N. A., Bunzow, J. R., Grandy, D., & Hoener, M. C. (2005). Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Genomics, 85(3), 372-385. https://doi.org/10.1016/j.ygeno.2004.11.010

    Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. / Lindemann, Lothar; Ebeling, Martin; Kratochwil, Nicole A.; Bunzow, James R.; Grandy, David; Hoener, Marius C.

    In: Genomics, Vol. 85, No. 3, 03.2005, p. 372-385.

    Research output: Contribution to journalArticle

    Lindemann, L, Ebeling, M, Kratochwil, NA, Bunzow, JR, Grandy, D & Hoener, MC 2005, 'Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors', Genomics, vol. 85, no. 3, pp. 372-385. https://doi.org/10.1016/j.ygeno.2004.11.010
    Lindemann, Lothar ; Ebeling, Martin ; Kratochwil, Nicole A. ; Bunzow, James R. ; Grandy, David ; Hoener, Marius C. / Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. In: Genomics. 2005 ; Vol. 85, No. 3. pp. 372-385.
    @article{734d98a3cc784c1faeb55b95185ee694,
    title = "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors",
    abstract = "Trace amines are endogenous compounds structurally related to classical biogenic amines that have been studied for decades, triggered by their link to psychiatric conditions of high epidemiological and economical relevance. The understanding of their pharmacology on the molecular level was hampered until the recent discovery of trace-amine-specific receptors. We completed the identification of all members of this novel GPCR family in human, chimpanzee, rat, and mouse and observed remarkable interspecies differences, even between human and chimpanzee. The analysis of the chromosomal localizations, phylogenetic relationships, and ligand pocket vectors reveals three distinct receptor subfamilies. As most of these receptors do not respond to trace amines, each subfamily will presumably have a distinct pharmacological profile, which remains to be identified. We propose a uniform nomenclature describing this novel GPCR family in all mammalian species as trace-amine-associated receptors (TAARs), which resolves the ambiguities and contradictions of the previous naming.",
    keywords = "Chimpanzee, GPCR, Nomenclature, Phylogeny, Trace amine",
    author = "Lothar Lindemann and Martin Ebeling and Kratochwil, {Nicole A.} and Bunzow, {James R.} and David Grandy and Hoener, {Marius C.}",
    year = "2005",
    month = "3",
    doi = "10.1016/j.ygeno.2004.11.010",
    language = "English (US)",
    volume = "85",
    pages = "372--385",
    journal = "Genomics",
    issn = "0888-7543",
    publisher = "Academic Press Inc.",
    number = "3",

    }

    TY - JOUR

    T1 - Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors

    AU - Lindemann, Lothar

    AU - Ebeling, Martin

    AU - Kratochwil, Nicole A.

    AU - Bunzow, James R.

    AU - Grandy, David

    AU - Hoener, Marius C.

    PY - 2005/3

    Y1 - 2005/3

    N2 - Trace amines are endogenous compounds structurally related to classical biogenic amines that have been studied for decades, triggered by their link to psychiatric conditions of high epidemiological and economical relevance. The understanding of their pharmacology on the molecular level was hampered until the recent discovery of trace-amine-specific receptors. We completed the identification of all members of this novel GPCR family in human, chimpanzee, rat, and mouse and observed remarkable interspecies differences, even between human and chimpanzee. The analysis of the chromosomal localizations, phylogenetic relationships, and ligand pocket vectors reveals three distinct receptor subfamilies. As most of these receptors do not respond to trace amines, each subfamily will presumably have a distinct pharmacological profile, which remains to be identified. We propose a uniform nomenclature describing this novel GPCR family in all mammalian species as trace-amine-associated receptors (TAARs), which resolves the ambiguities and contradictions of the previous naming.

    AB - Trace amines are endogenous compounds structurally related to classical biogenic amines that have been studied for decades, triggered by their link to psychiatric conditions of high epidemiological and economical relevance. The understanding of their pharmacology on the molecular level was hampered until the recent discovery of trace-amine-specific receptors. We completed the identification of all members of this novel GPCR family in human, chimpanzee, rat, and mouse and observed remarkable interspecies differences, even between human and chimpanzee. The analysis of the chromosomal localizations, phylogenetic relationships, and ligand pocket vectors reveals three distinct receptor subfamilies. As most of these receptors do not respond to trace amines, each subfamily will presumably have a distinct pharmacological profile, which remains to be identified. We propose a uniform nomenclature describing this novel GPCR family in all mammalian species as trace-amine-associated receptors (TAARs), which resolves the ambiguities and contradictions of the previous naming.

    KW - Chimpanzee

    KW - GPCR

    KW - Nomenclature

    KW - Phylogeny

    KW - Trace amine

    UR - http://www.scopus.com/inward/record.url?scp=13844275983&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=13844275983&partnerID=8YFLogxK

    U2 - 10.1016/j.ygeno.2004.11.010

    DO - 10.1016/j.ygeno.2004.11.010

    M3 - Article

    C2 - 15718104

    AN - SCOPUS:13844275983

    VL - 85

    SP - 372

    EP - 385

    JO - Genomics

    JF - Genomics

    SN - 0888-7543

    IS - 3

    ER -