Tpeak-to-Tend interval corrected for heart rate

A more precise measure of increased sudden death risk?

Kelvin C M Chua, Carmen Rusinaru, Kyndaron Reinier, Audrey Uy-Evanado, Harpriya Chugh, Karen Gunson, Jonathan Jui, Sumeet S. Chugh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background The Tpeak to Tend (Tpe) interval on the 12-lead electrocardiogram predicts an increased risk of sudden cardiac arrest (SCA). There is controversy over whether Tpe would be more useful if corrected for heart rate (Tpec). Objectives We evaluated whether the predictive value of Tpe for SCA improves with heart rate correction and sought to determine an optimal cutoff value for Tpec in the context of SCA risk. Methods Cases of SCA (n = 628; mean age 66.4 ± 14.5 years; n = 416, 66.2% men) from the Oregon Sudden Unexpected Death Study with an archived electrocardiogram available prior and unrelated to the SCA event were analyzed. Comparisons were made with control subjects (n = 819; mean age 66.7 ± 11.5 years; n = 559, 68.2% men). The Tpe interval was corrected for heart rate using Bazett (TpecBa) and Fridericia (TpecFd) formulas, and the predictive value of Tpec for SCA was evaluated using logistic regression models. Results The area under the curve for Tpec predicting SCA improved with both correction formulas. TpecBa and TpecFd were shown to have an area under the curve of 0.695 and 0.672, respectively, as compared with a baseline of 0.601 with an uncorrected Tpe. A TpecBa value of >90 ms was predictive of SCA, independent of age, sex, comorbidities, QRS duration, corrected QT interval, and severely reduced left ventricular ejection fraction (≤35%; odds ratio 2.8; 95% confidence interval 1.92–4.17; P <.0001). Conclusion Correcting Tpe for heart rate, using either the Bazett or the Fridericia formula, improved the independent predictive value of this marker for the assessment of SCA risk. Prolongation of TpecBa beyond 90 ms was associated with a nearly 3-fold increased risk of SCA.

Original languageEnglish (US)
Pages (from-to)2181-2185
Number of pages5
JournalHeart Rhythm
Volume13
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Sudden Cardiac Death
Sudden Death
Heart Rate
Area Under Curve
Electrocardiography
Logistic Models
Stroke Volume
Comorbidity
Odds Ratio
Confidence Intervals

Keywords

  • Cardiac arrest
  • Death
  • Prediction
  • Prevention
  • Risk
  • Stratification
  • sudden cardiac

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Chua, K. C. M., Rusinaru, C., Reinier, K., Uy-Evanado, A., Chugh, H., Gunson, K., ... Chugh, S. S. (2016). Tpeak-to-Tend interval corrected for heart rate: A more precise measure of increased sudden death risk? Heart Rhythm, 13(11), 2181-2185. https://doi.org/10.1016/j.hrthm.2016.08.022

Tpeak-to-Tend interval corrected for heart rate : A more precise measure of increased sudden death risk? / Chua, Kelvin C M; Rusinaru, Carmen; Reinier, Kyndaron; Uy-Evanado, Audrey; Chugh, Harpriya; Gunson, Karen; Jui, Jonathan; Chugh, Sumeet S.

In: Heart Rhythm, Vol. 13, No. 11, 01.11.2016, p. 2181-2185.

Research output: Contribution to journalArticle

Chua, KCM, Rusinaru, C, Reinier, K, Uy-Evanado, A, Chugh, H, Gunson, K, Jui, J & Chugh, SS 2016, 'Tpeak-to-Tend interval corrected for heart rate: A more precise measure of increased sudden death risk?', Heart Rhythm, vol. 13, no. 11, pp. 2181-2185. https://doi.org/10.1016/j.hrthm.2016.08.022
Chua, Kelvin C M ; Rusinaru, Carmen ; Reinier, Kyndaron ; Uy-Evanado, Audrey ; Chugh, Harpriya ; Gunson, Karen ; Jui, Jonathan ; Chugh, Sumeet S. / Tpeak-to-Tend interval corrected for heart rate : A more precise measure of increased sudden death risk?. In: Heart Rhythm. 2016 ; Vol. 13, No. 11. pp. 2181-2185.
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abstract = "Background The Tpeak to Tend (Tpe) interval on the 12-lead electrocardiogram predicts an increased risk of sudden cardiac arrest (SCA). There is controversy over whether Tpe would be more useful if corrected for heart rate (Tpec). Objectives We evaluated whether the predictive value of Tpe for SCA improves with heart rate correction and sought to determine an optimal cutoff value for Tpec in the context of SCA risk. Methods Cases of SCA (n = 628; mean age 66.4 ± 14.5 years; n = 416, 66.2{\%} men) from the Oregon Sudden Unexpected Death Study with an archived electrocardiogram available prior and unrelated to the SCA event were analyzed. Comparisons were made with control subjects (n = 819; mean age 66.7 ± 11.5 years; n = 559, 68.2{\%} men). The Tpe interval was corrected for heart rate using Bazett (TpecBa) and Fridericia (TpecFd) formulas, and the predictive value of Tpec for SCA was evaluated using logistic regression models. Results The area under the curve for Tpec predicting SCA improved with both correction formulas. TpecBa and TpecFd were shown to have an area under the curve of 0.695 and 0.672, respectively, as compared with a baseline of 0.601 with an uncorrected Tpe. A TpecBa value of >90 ms was predictive of SCA, independent of age, sex, comorbidities, QRS duration, corrected QT interval, and severely reduced left ventricular ejection fraction (≤35{\%}; odds ratio 2.8; 95{\%} confidence interval 1.92–4.17; P <.0001). Conclusion Correcting Tpe for heart rate, using either the Bazett or the Fridericia formula, improved the independent predictive value of this marker for the assessment of SCA risk. Prolongation of TpecBa beyond 90 ms was associated with a nearly 3-fold increased risk of SCA.",
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AU - Chua, Kelvin C M

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AU - Reinier, Kyndaron

AU - Uy-Evanado, Audrey

AU - Chugh, Harpriya

AU - Gunson, Karen

AU - Jui, Jonathan

AU - Chugh, Sumeet S.

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N2 - Background The Tpeak to Tend (Tpe) interval on the 12-lead electrocardiogram predicts an increased risk of sudden cardiac arrest (SCA). There is controversy over whether Tpe would be more useful if corrected for heart rate (Tpec). Objectives We evaluated whether the predictive value of Tpe for SCA improves with heart rate correction and sought to determine an optimal cutoff value for Tpec in the context of SCA risk. Methods Cases of SCA (n = 628; mean age 66.4 ± 14.5 years; n = 416, 66.2% men) from the Oregon Sudden Unexpected Death Study with an archived electrocardiogram available prior and unrelated to the SCA event were analyzed. Comparisons were made with control subjects (n = 819; mean age 66.7 ± 11.5 years; n = 559, 68.2% men). The Tpe interval was corrected for heart rate using Bazett (TpecBa) and Fridericia (TpecFd) formulas, and the predictive value of Tpec for SCA was evaluated using logistic regression models. Results The area under the curve for Tpec predicting SCA improved with both correction formulas. TpecBa and TpecFd were shown to have an area under the curve of 0.695 and 0.672, respectively, as compared with a baseline of 0.601 with an uncorrected Tpe. A TpecBa value of >90 ms was predictive of SCA, independent of age, sex, comorbidities, QRS duration, corrected QT interval, and severely reduced left ventricular ejection fraction (≤35%; odds ratio 2.8; 95% confidence interval 1.92–4.17; P <.0001). Conclusion Correcting Tpe for heart rate, using either the Bazett or the Fridericia formula, improved the independent predictive value of this marker for the assessment of SCA risk. Prolongation of TpecBa beyond 90 ms was associated with a nearly 3-fold increased risk of SCA.

AB - Background The Tpeak to Tend (Tpe) interval on the 12-lead electrocardiogram predicts an increased risk of sudden cardiac arrest (SCA). There is controversy over whether Tpe would be more useful if corrected for heart rate (Tpec). Objectives We evaluated whether the predictive value of Tpe for SCA improves with heart rate correction and sought to determine an optimal cutoff value for Tpec in the context of SCA risk. Methods Cases of SCA (n = 628; mean age 66.4 ± 14.5 years; n = 416, 66.2% men) from the Oregon Sudden Unexpected Death Study with an archived electrocardiogram available prior and unrelated to the SCA event were analyzed. Comparisons were made with control subjects (n = 819; mean age 66.7 ± 11.5 years; n = 559, 68.2% men). The Tpe interval was corrected for heart rate using Bazett (TpecBa) and Fridericia (TpecFd) formulas, and the predictive value of Tpec for SCA was evaluated using logistic regression models. Results The area under the curve for Tpec predicting SCA improved with both correction formulas. TpecBa and TpecFd were shown to have an area under the curve of 0.695 and 0.672, respectively, as compared with a baseline of 0.601 with an uncorrected Tpe. A TpecBa value of >90 ms was predictive of SCA, independent of age, sex, comorbidities, QRS duration, corrected QT interval, and severely reduced left ventricular ejection fraction (≤35%; odds ratio 2.8; 95% confidence interval 1.92–4.17; P <.0001). Conclusion Correcting Tpe for heart rate, using either the Bazett or the Fridericia formula, improved the independent predictive value of this marker for the assessment of SCA risk. Prolongation of TpecBa beyond 90 ms was associated with a nearly 3-fold increased risk of SCA.

KW - Cardiac arrest

KW - Death

KW - Prediction

KW - Prevention

KW - Risk

KW - Stratification

KW - sudden cardiac

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