TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding

Akira Ota, Zila Shen-Orr, Charles T. Roberts, Derek Leroith

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The neuroblastoma cell line SH-SY5Y was cultured in the presence of TPA for three days. Increased neurite formation was noted as early as 24 hours after TPA was added. These changes were associated with an increase in IGF-I receptor binding as well as increased mRNA for the IGF-I receptor.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalMolecular Brain Research
Volume6
Issue number1
DOIs
StatePublished - Jul 1989
Externally publishedYes

Keywords

  • 12-O-Tetradecanoyl-phorbol-13-acetate
  • Insulin-like growth factor I
  • Neuroblastoma
  • mRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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