The neuroblastoma cell line SH-SY5Y was cultured in the presence of TPA for three days. Increased neurite formation was noted as early as 24 hours after TPA was added. These changes were associated with an increase in IGF-I receptor binding as well as increased mRNA for the IGF-I receptor.
- Insulin-like growth factor I
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience