TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding

Akira Ota, Zila Shen-Orr, Charles T. Roberts, Derek Leroith

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    32 Scopus citations


    The neuroblastoma cell line SH-SY5Y was cultured in the presence of TPA for three days. Increased neurite formation was noted as early as 24 hours after TPA was added. These changes were associated with an increase in IGF-I receptor binding as well as increased mRNA for the IGF-I receptor.

    Original languageEnglish (US)
    Pages (from-to)69-76
    Number of pages8
    JournalMolecular Brain Research
    Issue number1
    StatePublished - Jul 1989



    • 12-O-Tetradecanoyl-phorbol-13-acetate
    • Insulin-like growth factor I
    • Neuroblastoma
    • mRNA

    ASJC Scopus subject areas

    • Molecular Biology
    • Cellular and Molecular Neuroscience

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