Toxicogenomic evaluation of nanomaterials

John M. Veranth; Sancy A. Leachman; Philip J. Moos

doi:10.1007/978-1-4614-5034-4_23

Toxicogenomic evaluation of nanomaterials

John M. Veranth, Sancy A. Leachman, Philip J. Moos

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The ongoing search for specialty substances with unique physical and chemical properties has motivated the development of numerous types of metal oxide nanomaterials, but concerns remain regarding biological effects of particles that are comparable in size to ultrafine air pollution (d < 100 nm). Much of the nanoparticle toxicological research has been on inhalation and intact-skin dermal exposures. Lung epithelial cells exposed to oxide nanoparticles show diverse responses, most notably upregulation of pro-inflammatory signaling pathways. This chapter addresses potential etiologies, mechanisms, and methodologies for investigating potential unforeseen toxicities of nanoparticles that are likely to occur in skin as nanoproducts become more and more available.

Original language	English (US)
Title of host publication	Nanotechnology in Dermatology
Publisher	Springer New York
Pages	253-260
Number of pages	8
Volume	9781461450344
ISBN (Electronic)	9781461450344
ISBN (Print)	1461450330, 9781461450337
DOIs	https://doi.org/10.1007/978-1-4614-5034-4_23
State	Published - Jul 1 2012
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-5034-4_23

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abstract = "The ongoing search for specialty substances with unique physical and chemical properties has motivated the development of numerous types of metal oxide nanomaterials, but concerns remain regarding biological effects of particles that are comparable in size to ultrafine air pollution (d < 100 nm). Much of the nanoparticle toxicological research has been on inhalation and intact-skin dermal exposures. Lung epithelial cells exposed to oxide nanoparticles show diverse responses, most notably upregulation of pro-inflammatory signaling pathways. This chapter addresses potential etiologies, mechanisms, and methodologies for investigating potential unforeseen toxicities of nanoparticles that are likely to occur in skin as nanoproducts become more and more available.",

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AU - Moos, Philip J.

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AB - The ongoing search for specialty substances with unique physical and chemical properties has motivated the development of numerous types of metal oxide nanomaterials, but concerns remain regarding biological effects of particles that are comparable in size to ultrafine air pollution (d < 100 nm). Much of the nanoparticle toxicological research has been on inhalation and intact-skin dermal exposures. Lung epithelial cells exposed to oxide nanoparticles show diverse responses, most notably upregulation of pro-inflammatory signaling pathways. This chapter addresses potential etiologies, mechanisms, and methodologies for investigating potential unforeseen toxicities of nanoparticles that are likely to occur in skin as nanoproducts become more and more available.

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VL - 9781461450344

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BT - Nanotechnology in Dermatology

PB - Springer New York

ER -

Toxicogenomic evaluation of nanomaterials

Abstract

ASJC Scopus subject areas

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