Toxicity of amphotericins on chronic administration to mongrel dogs

Paul D. Hoeprich; Alice C. Huston; Bruce M. Wolfe

doi:10.1016/0732-8893(85)90066-5

Toxicity of amphotericins on chronic administration to mongrel dogs

Paul D. Hoeprich, Alice C. Huston, Bruce M. Wolfe

Surgery

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Abstract

Conditioned mongrel dogs were given 30 i.v. injections of either AMB (amphotericin B, 0.75 mg/kg body weight), AME (amphotericin B methyl ester, 10 mg/kg body weight), or 5% glucose solution without antimicrobic. Severe loss of body weight and nephrotoxicity occurred with AMB; hepatic dysfunction resulted with AME; astrogliosis and pallor of the myelin were found in dogs given AME and 5% glucose solution.

Original language	English (US)
Pages (from-to)	47-58
Number of pages	12
Journal	Diagnostic Microbiology and Infectious Disease
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/0732-8893(85)90066-5
State	Published - Jan 1985

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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abstract = "Conditioned mongrel dogs were given 30 i.v. injections of either AMB (amphotericin B, 0.75 mg/kg body weight), AME (amphotericin B methyl ester, 10 mg/kg body weight), or 5% glucose solution without antimicrobic. Severe loss of body weight and nephrotoxicity occurred with AMB; hepatic dysfunction resulted with AME; astrogliosis and pallor of the myelin were found in dogs given AME and 5% glucose solution.",

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AB - Conditioned mongrel dogs were given 30 i.v. injections of either AMB (amphotericin B, 0.75 mg/kg body weight), AME (amphotericin B methyl ester, 10 mg/kg body weight), or 5% glucose solution without antimicrobic. Severe loss of body weight and nephrotoxicity occurred with AMB; hepatic dysfunction resulted with AME; astrogliosis and pallor of the myelin were found in dogs given AME and 5% glucose solution.

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Toxicity of amphotericins on chronic administration to mongrel dogs

Abstract

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