Conditioned mongrel dogs were given 30 i.v. injections of either AMB (amphotericin B, 0.75 mg/kg body weight), AME (amphotericin B methyl ester, 10 mg/kg body weight), or 5% glucose solution without antimicrobic. Severe loss of body weight and nephrotoxicity occurred with AMB; hepatic dysfunction resulted with AME; astrogliosis and pallor of the myelin were found in dogs given AME and 5% glucose solution.
|Original language||English (US)|
|Number of pages||12|
|Journal||Diagnostic Microbiology and Infectious Disease|
|State||Published - Jan 1985|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases