Toxicity of amphotericins on chronic administration to mongrel dogs

Paul D. Hoeprich, Alice C. Huston, Bruce M. Wolfe

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Conditioned mongrel dogs were given 30 i.v. injections of either AMB (amphotericin B, 0.75 mg/kg body weight), AME (amphotericin B methyl ester, 10 mg/kg body weight), or 5% glucose solution without antimicrobic. Severe loss of body weight and nephrotoxicity occurred with AMB; hepatic dysfunction resulted with AME; astrogliosis and pallor of the myelin were found in dogs given AME and 5% glucose solution.

Original languageEnglish (US)
Pages (from-to)47-58
Number of pages12
JournalDiagnostic Microbiology and Infectious Disease
Volume3
Issue number1
DOIs
StatePublished - Jan 1985

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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