Toxicity kinetics and clinical potential of subarachnoid lymphocyte infusions

Edward Neuwelt, D. Doherty

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The feasibility of intrathecal lymphocyte infusions was examined since patients with gliomas are known to have circulating, tumor-specific, cytotoxic lymphocytes. Human (xenogenic) and syngenic lymphocytes were infused intrathecally into rabbits, and the toxicity and kinetics of the infused cells evaluated. Cerebrospinal fluid cell counts rose to as high as 70,000 lymphocytes/cu mm 12 hours after infusion and then dropped logarithmically over several days. No infiltration of host cells into the subarachnoid space in response to the lymphocyte infusions was detected. Evidence is presented that intrathecally infused lymphocytes may escape into the systemic circulation. Toxicity was minimal, especially following syngenic intrathecal lymphocyte infusions. A systemic allergic response, characterized by choroid plexitis and pulmonary edema was noted following a second xenogenic but not after a second or even a third syngenic lymphocyte infusion.

Original languageEnglish (US)
Pages (from-to)205-217
Number of pages13
JournalJournal of Neurosurgery
Volume47
Issue number2
StatePublished - 1977
Externally publishedYes

Fingerprint

Lymphocytes
Subarachnoid Space
Choroid
Pulmonary Edema
Glioma
Cerebrospinal Fluid
Cell Count
Rabbits
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Toxicity kinetics and clinical potential of subarachnoid lymphocyte infusions. / Neuwelt, Edward; Doherty, D.

In: Journal of Neurosurgery, Vol. 47, No. 2, 1977, p. 205-217.

Research output: Contribution to journalArticle

@article{5c0b56b7beca4ad0a4c2132e95ee1c35,
title = "Toxicity kinetics and clinical potential of subarachnoid lymphocyte infusions",
abstract = "The feasibility of intrathecal lymphocyte infusions was examined since patients with gliomas are known to have circulating, tumor-specific, cytotoxic lymphocytes. Human (xenogenic) and syngenic lymphocytes were infused intrathecally into rabbits, and the toxicity and kinetics of the infused cells evaluated. Cerebrospinal fluid cell counts rose to as high as 70,000 lymphocytes/cu mm 12 hours after infusion and then dropped logarithmically over several days. No infiltration of host cells into the subarachnoid space in response to the lymphocyte infusions was detected. Evidence is presented that intrathecally infused lymphocytes may escape into the systemic circulation. Toxicity was minimal, especially following syngenic intrathecal lymphocyte infusions. A systemic allergic response, characterized by choroid plexitis and pulmonary edema was noted following a second xenogenic but not after a second or even a third syngenic lymphocyte infusion.",
author = "Edward Neuwelt and D. Doherty",
year = "1977",
language = "English (US)",
volume = "47",
pages = "205--217",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "2",

}

TY - JOUR

T1 - Toxicity kinetics and clinical potential of subarachnoid lymphocyte infusions

AU - Neuwelt, Edward

AU - Doherty, D.

PY - 1977

Y1 - 1977

N2 - The feasibility of intrathecal lymphocyte infusions was examined since patients with gliomas are known to have circulating, tumor-specific, cytotoxic lymphocytes. Human (xenogenic) and syngenic lymphocytes were infused intrathecally into rabbits, and the toxicity and kinetics of the infused cells evaluated. Cerebrospinal fluid cell counts rose to as high as 70,000 lymphocytes/cu mm 12 hours after infusion and then dropped logarithmically over several days. No infiltration of host cells into the subarachnoid space in response to the lymphocyte infusions was detected. Evidence is presented that intrathecally infused lymphocytes may escape into the systemic circulation. Toxicity was minimal, especially following syngenic intrathecal lymphocyte infusions. A systemic allergic response, characterized by choroid plexitis and pulmonary edema was noted following a second xenogenic but not after a second or even a third syngenic lymphocyte infusion.

AB - The feasibility of intrathecal lymphocyte infusions was examined since patients with gliomas are known to have circulating, tumor-specific, cytotoxic lymphocytes. Human (xenogenic) and syngenic lymphocytes were infused intrathecally into rabbits, and the toxicity and kinetics of the infused cells evaluated. Cerebrospinal fluid cell counts rose to as high as 70,000 lymphocytes/cu mm 12 hours after infusion and then dropped logarithmically over several days. No infiltration of host cells into the subarachnoid space in response to the lymphocyte infusions was detected. Evidence is presented that intrathecally infused lymphocytes may escape into the systemic circulation. Toxicity was minimal, especially following syngenic intrathecal lymphocyte infusions. A systemic allergic response, characterized by choroid plexitis and pulmonary edema was noted following a second xenogenic but not after a second or even a third syngenic lymphocyte infusion.

UR - http://www.scopus.com/inward/record.url?scp=0017710118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017710118&partnerID=8YFLogxK

M3 - Article

VL - 47

SP - 205

EP - 217

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - 2

ER -