Toxicities of topical ophthalmic anesthetics

Hall T. McGee, F. W. Fraunfelder

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

Topical ocular anesthesia has been part of ophthalmology for more than a century. The most commonly used drugs today are proparacaine, tetracaine, benoxinate (oxybuprocaine) cocaine and lidocaine. Although generally well tolerated, all these can be toxic, particularly when abused. The most common toxicities are to the ocular surface, but abuse can cause deep corneal infiltrates, ulceration and even perforation. Fortunately, systemic side effects are rare. Cocaine is unique for its higher incidence of systemic side effects and high abuse potential, both of which impede its clinical use. When used appropriately, all these drugs are remarkably safe. They are generally not prescribed for home use, as prolonged abuse of these drugs can be expected to result in serious complications.

Original languageEnglish (US)
Pages (from-to)637-640
Number of pages4
JournalExpert Opinion on Drug Safety
Volume6
Issue number6
DOIs
StatePublished - Nov 1 2007

Keywords

  • Antiemetics
  • Drug safety
  • NVP
  • Nausea and vomiting of pregnancy
  • Teratogenicity

ASJC Scopus subject areas

  • Pharmacology (medical)

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