Towards the rational design of MRI contrast agents: Electron spin relaxation is largely unaffected by the coordination geometry of gadolinium(III)-DOTA-type complexes

Alain Borel, Jonathan F. Bean, Robert B. Clarkson, Lothar Helm, Loïck Moriggi, A. Dean Sherry, Mark Woods

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Electron-spin relaxation is one of the determining factors in the efficacy of MRI contrast agents. Of all the parameters involved in determining relaxivity it remains the least well understood, particularly as it relates to the structure of the complex. One of the reasons for the poor understanding of electron-spin relaxation is that it is closely related to the ligand-field parameters of the Gd3+ ion that forms the basis of MRI contrast agents and these complexes generally exhibit a structural isomerism that inherently complicates the study of electron spin relaxation. We have recently shown that two DOTA-type ligands could be synthesised that, when coordinated to Gd3+, would adopt well defined coordination geometries and are not subject to the problems of intramolecular motion of other complexes. The EPR properties of these two chelates were studied and the results examined with theory to probe their electron-spin relaxation properties.

Original languageEnglish (US)
Pages (from-to)2658-2667
Number of pages10
JournalChemistry - A European Journal
Volume14
Issue number9
DOIs
StatePublished - Mar 17 2008

Keywords

  • Coordination geometry
  • EPR spectroscopy
  • Gadolinium
  • Imaging agents
  • Macrocyclic ligands

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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