Towards the rational design of MRI contrast agents: A practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange

Mark Woods, Mauro Botta, Stefano Avedano, Jing Wang, A. Dean Sherry

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

The gadolinium(III) complex of S-SSSS-NO2BnDOTMA exhibits water exchange kinetics that are optimal for use in high relaxivity or targeted contrast agents. However, the synthesis of this ligand is hampered by the steric encumbrance imparted upon the cyclen ring by the nitrobenzyl substituent. A relatively simple modification has been used to enable the synthesis of larger quantities of a bifunctional ligand that retains similar fast water exchange properties. The gadolinium complex of S-SSSS-NO2BnDO3MA-1A is shown to retain the rapid water exchange kinetics characteristic of a twisted square antiprismatic (TSAP) coordination geometry (τM = 6 ±0.4 ns).

Original languageEnglish (US)
Pages (from-to)3829-3837
Number of pages9
JournalDalton Transactions
Issue number24
DOIs
StatePublished - Dec 21 2005

ASJC Scopus subject areas

  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Towards the rational design of MRI contrast agents: A practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange'. Together they form a unique fingerprint.

  • Cite this