Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents: Isolation of the Two Coordination Isomers of Lanthanide DOTA-Type Complexes

Mark Woods; Zoltan Kovacs; Shanrong Zhang; A. Dean Sherry

doi:10.1002/anie.200352234

Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents: Isolation of the Two Coordination Isomers of Lanthanide DOTA-Type Complexes

Mark Woods, Zoltan Kovacs, Shanrong Zhang, A. Dean Sherry

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Controlling water exchange: Square antiprism (SAP; left) and twisted square antiprism (TSAP; right) coordination isomers of Ln^III" DOTA-type complexes (DOTA= 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) may be isolated by choosing substituents on the ring and arms with identical chirality for the TSAP isomer, or with opposite chirality for the SAP isomer. The water exchange rates of the complexes differ by an order of magnitude.

Original language	English (US)
Pages (from-to)	5889-5892
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	47
DOIs	https://doi.org/10.1002/anie.200352234
State	Published - Dec 8 2003
Externally published	Yes

Keywords

Coordination modes
Lanthanides
MRI contrast agents
Macrocyclic ligands

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.200352234

Cite this

@article{f87a6796df8142eaba67216db3a7b18d,

title = "Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents: Isolation of the Two Coordination Isomers of Lanthanide DOTA-Type Complexes",

abstract = "Controlling water exchange: Square antiprism (SAP; left) and twisted square antiprism (TSAP; right) coordination isomers of LnIII{"} DOTA-type complexes (DOTA= 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) may be isolated by choosing substituents on the ring and arms with identical chirality for the TSAP isomer, or with opposite chirality for the SAP isomer. The water exchange rates of the complexes differ by an order of magnitude.",

keywords = "Coordination modes, Lanthanides, MRI contrast agents, Macrocyclic ligands",

author = "Mark Woods and Zoltan Kovacs and Shanrong Zhang and Sherry, {A. Dean}",

year = "2003",

month = dec,

day = "8",

doi = "10.1002/anie.200352234",

language = "English (US)",

volume = "42",

pages = "5889--5892",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "47",

}

TY - JOUR

T1 - Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents

T2 - Isolation of the Two Coordination Isomers of Lanthanide DOTA-Type Complexes

AU - Woods, Mark

AU - Kovacs, Zoltan

AU - Zhang, Shanrong

AU - Sherry, A. Dean

PY - 2003/12/8

Y1 - 2003/12/8

N2 - Controlling water exchange: Square antiprism (SAP; left) and twisted square antiprism (TSAP; right) coordination isomers of LnIII" DOTA-type complexes (DOTA= 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) may be isolated by choosing substituents on the ring and arms with identical chirality for the TSAP isomer, or with opposite chirality for the SAP isomer. The water exchange rates of the complexes differ by an order of magnitude.

AB - Controlling water exchange: Square antiprism (SAP; left) and twisted square antiprism (TSAP; right) coordination isomers of LnIII" DOTA-type complexes (DOTA= 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) may be isolated by choosing substituents on the ring and arms with identical chirality for the TSAP isomer, or with opposite chirality for the SAP isomer. The water exchange rates of the complexes differ by an order of magnitude.

KW - Coordination modes

KW - Lanthanides

KW - MRI contrast agents

KW - Macrocyclic ligands

UR - http://www.scopus.com/inward/record.url?scp=0348048763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0348048763&partnerID=8YFLogxK

U2 - 10.1002/anie.200352234

DO - 10.1002/anie.200352234

M3 - Article

C2 - 14673928

AN - SCOPUS:0348048763

SN - 1433-7851

VL - 42

SP - 5889

EP - 5892

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 47

ER -

Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents: Isolation of the Two Coordination Isomers of Lanthanide DOTA-Type Complexes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this