Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents: Isolation of the Two Coordination Isomers of Lanthanide DOTA-Type Complexes

Mark Woods, Zoltan Kovacs, Shanrong Zhang, A. Dean Sherry

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Controlling water exchange: Square antiprism (SAP; left) and twisted square antiprism (TSAP; right) coordination isomers of LnIII" DOTA-type complexes (DOTA= 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) may be isolated by choosing substituents on the ring and arms with identical chirality for the TSAP isomer, or with opposite chirality for the SAP isomer. The water exchange rates of the complexes differ by an order of magnitude.

Original languageEnglish (US)
Pages (from-to)5889-5892
Number of pages4
JournalAngewandte Chemie - International Edition
Volume42
Issue number47
DOIs
StatePublished - Dec 8 2003
Externally publishedYes

Fingerprint

Lanthanoid Series Elements
Rare earth elements
Isomers
Contrast Media
Chirality
Water
Acids
Magnetic Resonance Imaging

Keywords

  • Coordination modes
  • Lanthanides
  • Macrocyclic ligands
  • MRI contrast agents

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents : Isolation of the Two Coordination Isomers of Lanthanide DOTA-Type Complexes. / Woods, Mark; Kovacs, Zoltan; Zhang, Shanrong; Sherry, A. Dean.

In: Angewandte Chemie - International Edition, Vol. 42, No. 47, 08.12.2003, p. 5889-5892.

Research output: Contribution to journalArticle

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