Towards improved animal models of neonatal white matter injury associated with cerebral palsy

John C. Silbereis, Eric J. Huang, Stephen A. Back, David H. Rowitch

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

Newborn neurological injuries are the leading cause of intellectual and motor disabilities that are associated with cerebral palsy. Cerebral white matter injury is a common feature in hypoxic-ischemic encephalopathy (HIE), which affects fullterm infants, and in periventricular leukomalacia (PVL), which affects preterm infants. This article discusses recent efforts to model neonatal white matter injury using mammalian systems. We emphasize that a comprehensive understanding of oligodendrocyte development and physiology is crucial for obtaining new insights into the pathobiology of HIE and PVL as well as for the generation of more sophisticated and faithful animal models.

Original languageEnglish (US)
Pages (from-to)678-688
Number of pages11
JournalDMM Disease Models and Mechanisms
Volume3
Issue number11-12
DOIs
StatePublished - Nov 1 2010

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ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Medicine (miscellaneous)
  • Immunology and Microbiology (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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