Towards an understanding of the adjuvant action of aluminium

Philippa Marrack, Amy S. McKee, Michael Munks

Research output: Contribution to journalArticle

462 Citations (Scopus)

Abstract

The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalNature Reviews Immunology
Volume9
Issue number4
DOIs
StatePublished - Apr 2009
Externally publishedYes

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Aluminum
Vaccines
Antigens
TimeLine

ASJC Scopus subject areas

  • Immunology

Cite this

Towards an understanding of the adjuvant action of aluminium. / Marrack, Philippa; McKee, Amy S.; Munks, Michael.

In: Nature Reviews Immunology, Vol. 9, No. 4, 04.2009, p. 287-293.

Research output: Contribution to journalArticle

Marrack, Philippa ; McKee, Amy S. ; Munks, Michael. / Towards an understanding of the adjuvant action of aluminium. In: Nature Reviews Immunology. 2009 ; Vol. 9, No. 4. pp. 287-293.
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