Towards an understanding of the adjuvant action of aluminium

Philippa Marrack, Amy S. McKee, Michael W. Munks

Research output: Contribution to journalReview article

480 Scopus citations

Abstract

The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalNature Reviews Immunology
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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