Towards an understanding of the adjuvant action of aluminium

Philippa Marrack; Amy S. McKee; Michael W. Munks

doi:10.1038/nri2510

Towards an understanding of the adjuvant action of aluminium

Philippa Marrack, Amy S. McKee, Michael W. Munks

Research output: Contribution to journal › Review article › peer-review

658 Scopus citations

Abstract

The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.

Original language	English (US)
Pages (from-to)	287-293
Number of pages	7
Journal	Nature Reviews Immunology
Volume	9
Issue number	4
DOIs	https://doi.org/10.1038/nri2510
State	Published - Apr 2009
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/nri2510

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title = "Towards an understanding of the adjuvant action of aluminium",

abstract = "The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.",

author = "Philippa Marrack and McKee, {Amy S.} and Munks, {Michael W.}",

note = "Funding Information: This work was partially supported by the US Public Health Service Commissioned Corps (grants A1-18785 and A1-22995).",

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AB - The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.

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Towards an understanding of the adjuvant action of aluminium

Abstract

ASJC Scopus subject areas

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