Towards a non-invasive interictal application of hypothermia for treating seizures

A feasibility and pilot study

A. Bagić, W. H. Theodore, Eilis Boudreau, R. Bonwetsch, J. Greenfield, W. Elkins, S. Sato

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives - To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering. Patients and methods - We used a non-invasive head-neck cooling system (CoolSystems Inc., Lincoln, CA, USA). The tympanic temperature (TT) and intestinal temperature (IT) were measured as two measurements of 'core temperature' (CT), and multi-site external temperatures, several physiologic variables and EEG were monitored. Seizure counts over 4-week precooling, treatment and follow-up phases were compared. Results - All 15 participants completed all the cooling sessions without significant complaints. At the end of 60 min of cooling, scalp temperature fell on average by 12.2°C (P <0.001), TT by 1.67°C (P <0.001), and IT by 0.12°C (P = NS). Average weekly seizure frequency decreased from 2.7 to 1.7 events per patient per week (MANOVA: P <0.05). Conclusions - Non-invasive head-neck cooling is safe and well-tolerated. Initial pilot data in patients suggest that additional therapeutic studies are warranted.

Original languageEnglish (US)
Pages (from-to)240-244
Number of pages5
JournalActa Neurologica Scandinavica
Volume118
Issue number4
DOIs
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

Feasibility Studies
Hypothermia
Seizures
Temperature
Neck
Head
Shivering
Scalp
Electroencephalography
Epilepsy
Healthy Volunteers
Safety
Therapeutics

Keywords

  • Brain
  • Core temperature
  • Cortical excitability
  • Epilepsy
  • Interictal cooling
  • Non-invasive hypothermia
  • Seizures
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Towards a non-invasive interictal application of hypothermia for treating seizures : A feasibility and pilot study. / Bagić, A.; Theodore, W. H.; Boudreau, Eilis; Bonwetsch, R.; Greenfield, J.; Elkins, W.; Sato, S.

In: Acta Neurologica Scandinavica, Vol. 118, No. 4, 10.2008, p. 240-244.

Research output: Contribution to journalArticle

Bagić, A. ; Theodore, W. H. ; Boudreau, Eilis ; Bonwetsch, R. ; Greenfield, J. ; Elkins, W. ; Sato, S. / Towards a non-invasive interictal application of hypothermia for treating seizures : A feasibility and pilot study. In: Acta Neurologica Scandinavica. 2008 ; Vol. 118, No. 4. pp. 240-244.
@article{f4083d7c40ec49e6ba216faa4e140273,
title = "Towards a non-invasive interictal application of hypothermia for treating seizures: A feasibility and pilot study",
abstract = "Objectives - To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering. Patients and methods - We used a non-invasive head-neck cooling system (CoolSystems Inc., Lincoln, CA, USA). The tympanic temperature (TT) and intestinal temperature (IT) were measured as two measurements of 'core temperature' (CT), and multi-site external temperatures, several physiologic variables and EEG were monitored. Seizure counts over 4-week precooling, treatment and follow-up phases were compared. Results - All 15 participants completed all the cooling sessions without significant complaints. At the end of 60 min of cooling, scalp temperature fell on average by 12.2°C (P <0.001), TT by 1.67°C (P <0.001), and IT by 0.12°C (P = NS). Average weekly seizure frequency decreased from 2.7 to 1.7 events per patient per week (MANOVA: P <0.05). Conclusions - Non-invasive head-neck cooling is safe and well-tolerated. Initial pilot data in patients suggest that additional therapeutic studies are warranted.",
keywords = "Brain, Core temperature, Cortical excitability, Epilepsy, Interictal cooling, Non-invasive hypothermia, Seizures, Treatment",
author = "A. Bagić and Theodore, {W. H.} and Eilis Boudreau and R. Bonwetsch and J. Greenfield and W. Elkins and S. Sato",
year = "2008",
month = "10",
doi = "10.1111/j.1600-0404.2008.01008.x",
language = "English (US)",
volume = "118",
pages = "240--244",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Towards a non-invasive interictal application of hypothermia for treating seizures

T2 - A feasibility and pilot study

AU - Bagić, A.

AU - Theodore, W. H.

AU - Boudreau, Eilis

AU - Bonwetsch, R.

AU - Greenfield, J.

AU - Elkins, W.

AU - Sato, S.

PY - 2008/10

Y1 - 2008/10

N2 - Objectives - To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering. Patients and methods - We used a non-invasive head-neck cooling system (CoolSystems Inc., Lincoln, CA, USA). The tympanic temperature (TT) and intestinal temperature (IT) were measured as two measurements of 'core temperature' (CT), and multi-site external temperatures, several physiologic variables and EEG were monitored. Seizure counts over 4-week precooling, treatment and follow-up phases were compared. Results - All 15 participants completed all the cooling sessions without significant complaints. At the end of 60 min of cooling, scalp temperature fell on average by 12.2°C (P <0.001), TT by 1.67°C (P <0.001), and IT by 0.12°C (P = NS). Average weekly seizure frequency decreased from 2.7 to 1.7 events per patient per week (MANOVA: P <0.05). Conclusions - Non-invasive head-neck cooling is safe and well-tolerated. Initial pilot data in patients suggest that additional therapeutic studies are warranted.

AB - Objectives - To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering. Patients and methods - We used a non-invasive head-neck cooling system (CoolSystems Inc., Lincoln, CA, USA). The tympanic temperature (TT) and intestinal temperature (IT) were measured as two measurements of 'core temperature' (CT), and multi-site external temperatures, several physiologic variables and EEG were monitored. Seizure counts over 4-week precooling, treatment and follow-up phases were compared. Results - All 15 participants completed all the cooling sessions without significant complaints. At the end of 60 min of cooling, scalp temperature fell on average by 12.2°C (P <0.001), TT by 1.67°C (P <0.001), and IT by 0.12°C (P = NS). Average weekly seizure frequency decreased from 2.7 to 1.7 events per patient per week (MANOVA: P <0.05). Conclusions - Non-invasive head-neck cooling is safe and well-tolerated. Initial pilot data in patients suggest that additional therapeutic studies are warranted.

KW - Brain

KW - Core temperature

KW - Cortical excitability

KW - Epilepsy

KW - Interictal cooling

KW - Non-invasive hypothermia

KW - Seizures

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=51349139858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51349139858&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0404.2008.01008.x

DO - 10.1111/j.1600-0404.2008.01008.x

M3 - Article

VL - 118

SP - 240

EP - 244

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 4

ER -